DegronMD - Q6VY07(PACS1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E389Q	TCGA-43-8118	LUSC	TCGA	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation rewiring degron network	0.0556
p.E389Q	DO45471	LUSC	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation rewiring degron network	0.0556
p.R790Q	TCGA-A8-A06Q	BRCA	TCGA	VPSTS	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.0833
p.R790Q	TCGA-A8-A06Q	BRCA	TCGA	PPSSS	DEG_SPOP_SBC_1	782:786	Mutation rewiring degron network	0.2222
p.Q408R	TCGA-AP-A1DK	UCEC	TCGA	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation rewiring degron network	0.2222
p.Q408R	DO42033	UCEC	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation rewiring degron network	0.2222
p.P395L	TCGA-CZ-5459	KIRC	TCGA	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation rewiring degron network	0.2222
p.P395L	DO17452	KIRC	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation rewiring degron network	0.2222
p.G767W	TCGA-D1-A174	UCEC	TCGA	VPSTS	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.0556
p.L473V	TCGA-DK-A3X1	BLCA	TCGA	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.1667
p.S407L	TCGA-EE-A29D	SKCM	TCGA	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation blocking phosphorylation signal	0.6944
p.S407L	DO38123	SKCM	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation blocking phosphorylation signal	0.6944
p.P771S	TCGA-EE-A2M5	SKCM	TCGA	VPSTS	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.1667
p.P401S	TCGA-EE-A2MR	SKCM	TCGA	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation altering degron motif	0.6752
p.P401S	DO37819	SKCM	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation altering degron motif	0.6752
p.S786L	TCGA-EO-A22X	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	782:786	Mutation altering degron motif	0.7667
p.S786L	TCGA-FI-A2D0	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	782:786	Mutation altering degron motif	0.7667
p.F402L	TCGA-EY-A1G8	UCEC	TCGA	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation altering degron motif	0.6981
p.F402L	DO43578	UCEC	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation altering degron motif	0.6981
p.T394M	TCGA-FI-A2D5	UCEC	TCGA	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation blocking phosphorylation signal	0.6389
p.T394M	TCGA-KQ-A41S	BLCA	TCGA	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation blocking phosphorylation signal	0.6389
p.T394M	DO223593	BLCA	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation blocking phosphorylation signal	0.6389
p.T394M	DO41331	UCEC	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation blocking phosphorylation signal	0.6389
p.P482S	TCGA-W3-A824	SKCM	TCGA	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation altering degron motif	0.6752
p.S67C	DO3922	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.7541
p.S76N	DO44220	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1111
p.S70F	DO49896	CESC	ICGC	AASSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.2778
p.F474L	DO8264	COAD	ICGC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.1944
p.F474L	DO43041	UCEC	ICGC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.1944
p.T77M	DO227996	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0833
p.T77M	DO13462	GBM	ICGC	AASSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0833
p.M411I	DO234388	ESAD	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation blocking phosphorylation signal	0.5833
p.S68L	DO223014	ESCA	ICGC	AASSS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.8778
p.S68L	DO220906	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.8778
p.S393N	DO233903	GACA	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation rewiring degron network	0.1667
p.S391L	DO15286	HNSC	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation rewiring degron network	0.1111
p.E414D	DO228948	LICA	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation rewiring degron network	0.0556
p.R390L	DO228974	LICA	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation rewiring degron network	0.0833
p.S400I	DO229022	LICA	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation altering degron motif	0.7341
p.P48H	DO231580	LINC	ICGC	ATSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1944
p.R69C	DO228177	PBCA	ICGC	AASSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.3056
p.D66N	DO38495	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.6932
p.A64T	DO229218	THCA	ICGC	AASSS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.7139
p.L392H	DO229221	THCA	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation rewiring degron network	0.1389
p.T483I	DO41044	UCEC	ICGC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation altering degron motif	0.7078
p.H75Q	DO41014	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1389
p.S494G	DO223282	UCEC	ICGC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.0833
p.T47M	DO42977	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.T47M	SNU-407	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.S406A	DO41903	UCEC	ICGC	LKPFFE	LIG_APCC_ABBA_1	399:404	Mutation rewiring degron network	0.2778
p.V490M	DO41999	UCEC	ICGC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.1944
p.H487Y	DO42472	UCEC	ICGC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.2778
p.S495F	SIDM01175	Other Sarcomas	GDSC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation blocking phosphorylation signal	0.5
p.S495F	ACH-002309	Sarcoma	CCLE	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation blocking phosphorylation signal	0.5
p.S495F	SW684	soft tissue	COSMIC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation blocking phosphorylation signal	0.5
p.V474I	SIDM00239	Kidney Carcinoma	GDSC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.1944
p.V474I	SIDM01691	Chronic Myelogenous Leukemia	GDSC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.1944
p.V474I	ACH-000159	Kidney Cancer	CCLE	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.1944
p.V474I	ACH-000321	Leukemia	CCLE	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.1944
p.V474I	OS-RC-2	kidney	COSMIC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.1944
p.A469V	SIDM00537	Colorectal Carcinoma	GDSC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.0556
p.A469V	ACH-000982	Colon/Colorectal Cancer	CCLE	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.0556
p.A469V	ACH-001345	Colon/Colorectal Cancer	CCLE	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.0556
p.A469V	GP5d	large intestine	COSMIC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.0556
p.M483V	SIDM00217	Colorectal Carcinoma	GDSC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation altering degron motif	0.6097
p.M483V	ACH-000999	Colon/Colorectal Cancer	CCLE	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation altering degron motif	0.6097
p.M483V	SNU-1040	large intestine	COSMIC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation altering degron motif	0.6097
p.P778S	SIDM00153	T-Lymphoblastic Leukemia	GDSC	VPSTS	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.5641
p.P778S	ACH-000964	Leukemia	CCLE	VPSTS	DEG_SPOP_SBC_1	777:781	Mutation altering degron motif	0.5641
p.T776S	ACH-000533	Rhabdoid	CCLE	VPSTS	DEG_SPOP_SBC_1	777:781	Mutation rewiring degron network	0.3056
p.T776S	ACH-000533	Rhabdoid	CCLE	PPSSS	DEG_SPOP_SBC_1	782:786	Mutation rewiring degron network	0.1667
p.K46E	ACH-000811	Ovarian Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	53:57	Mutation blocking phosphorylation signal	0.5833
p.K46E	SK-OV-3	ovary	COSMIC	ATSSS	DEG_SPOP_SBC_1	53:57	Mutation blocking phosphorylation signal	0.5833
p.K78R	ACH-000955	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0556
p.K78R	SNU-407	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0556
p.T54P	ACH-000975	Lung Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.5919
p.A77D	ACH-000994	Endometrial/Uterine Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0833
p.R52W	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.3056
p.K486R	SNU-407	large intestine	COSMIC	VKTPMKS	DEG_SCF_FBW7_1	479:485	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PACS1

UniProt ID: Q6VY07

Entrez ID: 55690

Protein name: Phosphofurin acidic cluster sorting protein 1 (PACS-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PACS1 in