DegronMD

Uniprot ID: Q6VY07

Source protein: Phosphofurin acidic cluster sorting protein 1

Source gene: PACS1

Class: LIG_APCC_ABBA_1

Location: 399:404

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.995

ASA_SCORE: 81.85

COIL: 0.6542

CONS_SCORE: 0.6265

DSS_SCORE: 0.6288

HELIX: 0.1915

FCONS_SCORE: 1.2967

RIG_SCORE: 0.7257

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E389Q	TCGA-43-8118	LUSC	TCGA	LKPFFE	LIG_APCC_ABBA_1	0.0556
p.E389Q	DO45471	LUSC	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.0556
p.Q408R	TCGA-AP-A1DK	UCEC	TCGA	LKPFFE	LIG_APCC_ABBA_1	0.2222
p.Q408R	DO42033	UCEC	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.2222
p.P395L	TCGA-CZ-5459	KIRC	TCGA	LKPFFE	LIG_APCC_ABBA_1	0.2222
p.P395L	DO17452	KIRC	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.2222
p.S407L	TCGA-EE-A29D	SKCM	TCGA	LKPFFE	LIG_APCC_ABBA_1	0.6944
p.S407L	DO38123	SKCM	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.6944
p.P401S	TCGA-EE-A2MR	SKCM	TCGA	LKPFFE	LIG_APCC_ABBA_1	0.6752
p.P401S	DO37819	SKCM	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.6752
p.F402L	TCGA-EY-A1G8	UCEC	TCGA	LKPFFE	LIG_APCC_ABBA_1	0.6981
p.F402L	DO43578	UCEC	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.6981
p.T394M	TCGA-FI-A2D5	UCEC	TCGA	LKPFFE	LIG_APCC_ABBA_1	0.6389
p.T394M	TCGA-KQ-A41S	BLCA	TCGA	LKPFFE	LIG_APCC_ABBA_1	0.6389
p.T394M	DO223593	BLCA	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.6389
p.T394M	DO41331	UCEC	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.6389
p.M411I	DO234388	ESAD	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.5833
p.S393N	DO233903	GACA	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.1667
p.S391L	DO15286	HNSC	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.1111
p.E414D	DO228948	LICA	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.0556
p.R390L	DO228974	LICA	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.0833
p.S400I	DO229022	LICA	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.7341
p.L392H	DO229221	THCA	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.1389
p.S406A	DO41903	UCEC	ICGC	LKPFFE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6VY07	Phosphofurin acidic cluster sorting protein 1	LIG_APCC_ABBA_1	399:404	LKPFFE	APC,CDC20,FZR1	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons