DegronMD

Uniprot ID: Q6VY07

Source protein: Phosphofurin acidic cluster sorting protein 1

Source gene: PACS1

Class: DEG_SCF_FBW7_1

Location: 479:485

E3 ligase: FBXW7

DEGRON score: 0.978

ASA_SCORE: 96.0429

COIL: 0.8991

CONS_SCORE: 0.4074

DSS_SCORE: 0.586

HELIX: 0.0731

FCONS_SCORE: 1.1009

RIG_SCORE: 0.6976

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L473V	TCGA-DK-A3X1	BLCA	TCGA	VKTPMKS	DEG_SCF_FBW7_1	0.1667
p.P482S	TCGA-W3-A824	SKCM	TCGA	VKTPMKS	DEG_SCF_FBW7_1	0.6752
p.F474L	DO8264	COAD	ICGC	VKTPMKS	DEG_SCF_FBW7_1	0.1944
p.F474L	DO43041	UCEC	ICGC	VKTPMKS	DEG_SCF_FBW7_1	0.1944
p.T483I	DO41044	UCEC	ICGC	VKTPMKS	DEG_SCF_FBW7_1	0.7078
p.S494G	DO223282	UCEC	ICGC	VKTPMKS	DEG_SCF_FBW7_1	0.0833
p.V490M	DO41999	UCEC	ICGC	VKTPMKS	DEG_SCF_FBW7_1	0.1944
p.H487Y	DO42472	UCEC	ICGC	VKTPMKS	DEG_SCF_FBW7_1	0.2778
p.S495F	SIDM01175	Other Sarcomas	GDSC	VKTPMKS	DEG_SCF_FBW7_1	0.5
p.S495F	ACH-002309	Sarcoma	CCLE	VKTPMKS	DEG_SCF_FBW7_1	0.5
p.S495F	SW684	soft_tissue	COSMIC	VKTPMKS	DEG_SCF_FBW7_1	0.5
p.V474I	SIDM00239	Kidney Carcinoma	GDSC	VKTPMKS	DEG_SCF_FBW7_1	0.1944
p.V474I	SIDM01691	Chronic Myelogenous Leukemia	GDSC	VKTPMKS	DEG_SCF_FBW7_1	0.1944
p.V474I	ACH-000159	Kidney Cancer	CCLE	VKTPMKS	DEG_SCF_FBW7_1	0.1944
p.V474I	ACH-000321	Leukemia	CCLE	VKTPMKS	DEG_SCF_FBW7_1	0.1944
p.V474I	OS-RC-2	kidney	COSMIC	VKTPMKS	DEG_SCF_FBW7_1	0.1944
p.A469V	SIDM00537	Colorectal Carcinoma	GDSC	VKTPMKS	DEG_SCF_FBW7_1	0.0556
p.A469V	ACH-000982	Colon/Colorectal Cancer	CCLE	VKTPMKS	DEG_SCF_FBW7_1	0.0556
p.A469V	ACH-001345	Colon/Colorectal Cancer	CCLE	VKTPMKS	DEG_SCF_FBW7_1	0.0556
p.A469V	GP5d	large_intestine	COSMIC	VKTPMKS	DEG_SCF_FBW7_1	0.0556
p.M483V	SIDM00217	Colorectal Carcinoma	GDSC	VKTPMKS	DEG_SCF_FBW7_1	0.6097
p.M483V	ACH-000999	Colon/Colorectal Cancer	CCLE	VKTPMKS	DEG_SCF_FBW7_1	0.6097
p.M483V	SNU-1040	large_intestine	COSMIC	VKTPMKS	DEG_SCF_FBW7_1	0.6097
p.K486R	SNU-407	large_intestine	COSMIC	VKTPMKS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6VY07	Phosphofurin acidic cluster sorting protein 1	DEG_SCF_FBW7_1	479:485	VKTPMKS	FBXW7	0.978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons