DegronMD - Q9Y4H2(IRS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G855R	TCGA-2G-AAGF	TGCT	TCGA	PQATPGPS	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.1389
p.A942T	DO222973	BTCA	ICGC	AASSS	DEG_SPOP_SBC_1	942:946	Mutation altering degron motif	0.7139
p.A940S	DO222760	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.2778
p.T891M	DO234336	ESAD	ICGC	TRLSLEGLP	DEG_APCC_DBOX_1	891:899	Mutation altering degron motif	0.7423
p.A951T	DO233935	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.1944
p.A951T	SIDM01608	Endometrial Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.1944
p.A951T	ACH-000990	Endometrial/Uterine Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.1944
p.A935V	DO12034	GBM	ICGC	AASSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.1389
p.A853D	DO228948	LICA	ICGC	PQATPGPS	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.1944
p.H905R	DO228338	MALY	ICGC	TRLSLEGLP	DEG_APCC_DBOX_1	891:899	Mutation rewiring degron network	0.1667
p.E896K	DO222402	MELA	ICGC	TRLSLEGLP	DEG_APCC_DBOX_1	891:899	Mutation altering degron motif	0.591
p.Y907N	DO49141	PACA	ICGC	TRLSLEGLP	DEG_APCC_DBOX_1	891:899	Mutation rewiring degron network	0.1111
p.L839P	DO229192	THCA	ICGC	PQATPGPS	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.2778
p.L839P	SIDM00205	Ewing's Sarcoma	GDSC	PQATPGPS	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.2778
p.E906D	DO229208	THCA	ICGC	TRLSLEGLP	DEG_APCC_DBOX_1	891:899	Mutation rewiring degron network	0.1389
p.G961D	DO229201	THCA	ICGC	PGTSS	DEG_SPOP_SBC_1	963:967	Mutation rewiring degron network	0.2778
p.R892C	DO229216	THCA	ICGC	TRLSLEGLP	DEG_APCC_DBOX_1	891:899	Mutation altering degron motif	0.8301
p.A856S	DO229232	THCA	ICGC	PQATPGPS	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.1111
p.S973F	DO229085	THCA	ICGC	PGTSS	DEG_SPOP_SBC_1	963:967	Mutation blocking phosphorylation signal	0.6111
p.M904I	ACH-000317	Kidney Cancer	CCLE	TRLSLEGLP	DEG_APCC_DBOX_1	891:899	Mutation rewiring degron network	0.1944
p.S941L	ACH-000552	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.3056
p.G897E	ACH-000710	Lung Cancer	CCLE	TRLSLEGLP	DEG_APCC_DBOX_1	891:899	Mutation altering degron motif	0.6087
p.P934A	ACH-000730	Skin Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.1111
p.R832C	ACH-000985	Colon/Colorectal Cancer	CCLE	PQATPGPS	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.0833
p.D968N	ACH-000989	Colon/Colorectal Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	963:967	Mutation rewiring degron network	0.3056
p.A940V	ACH-000999	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	942:946	Mutation rewiring degron network	0.2778
p.S900T	ACH-001495	Endometrial/Uterine Cancer	CCLE	TRLSLEGLP	DEG_APCC_DBOX_1	891:899	Mutation rewiring degron network	0.3056
p.A853G	ACH-001638	Lymphoma	CCLE	PQATPGPS	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.1944
p.R886Q	ACH-001652	Endometrial/Uterine Cancer	CCLE	TRLSLEGLP	DEG_APCC_DBOX_1	891:899	Mutation rewiring degron network	0.1944
p.M904V	ACH-002048	Sarcoma	CCLE	TRLSLEGLP	DEG_APCC_DBOX_1	891:899	Mutation rewiring degron network	0.1944

Kaplan plot for IRS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRS2

UniProt ID: Q9Y4H2

Entrez ID: 8660

Protein name: Insulin receptor substrate 2 (IRS-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRS2 in