DegronMD

Uniprot ID: Q9Y4H2

Source protein: Insulin receptor substrate 2

Source gene: IRS2

Class: DEG_SCF_FBW7_1

Location: 841:848

E3 ligase: FBXW7

DEGRON score: 0.9083

ASA_SCORE: 84.7875

COIL: 0.938

CONS_SCORE: 0.2269

DSS_SCORE: 0.7449

HELIX: 0.0445

FCONS_SCORE: -0.005

RIG_SCORE: 0.596

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G855R	TCGA-2G-AAGF	TGCT	TCGA	PQATPGPS	DEG_SCF_FBW7_1	0.1389
p.A853D	DO228948	LICA	ICGC	PQATPGPS	DEG_SCF_FBW7_1	0.1944
p.L839P	DO229192	THCA	ICGC	PQATPGPS	DEG_SCF_FBW7_1	0.2778
p.L839P	SIDM00205	Ewing's Sarcoma	GDSC	PQATPGPS	DEG_SCF_FBW7_1	0.2778
p.A856S	DO229232	THCA	ICGC	PQATPGPS	DEG_SCF_FBW7_1	0.1111
p.R832C	ACH-000985	Colon/Colorectal Cancer	CCLE	PQATPGPS	DEG_SCF_FBW7_1	0.0833
p.A853G	ACH-001638	Lymphoma	CCLE	PQATPGPS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4H2	Insulin receptor substrate 2	DEG_SCF_FBW7_1	841:848	PQATPGPS	FBXW7	0.9083	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons