DegronMD

Uniprot ID: Q9Y4H2

Source protein: Insulin receptor substrate 2

Source gene: IRS2

Class: DEG_APCC_DBOX_1

Location: 891:899

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.822

ASA_SCORE: 92.1222

COIL: 0.9033

CONS_SCORE: 0.4797

DSS_SCORE: 0.562

HELIX: 0.062

FCONS_SCORE: 1.185

RIG_SCORE: 0.6719

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T891M	DO234336	ESAD	ICGC	TRLSLEGLP	DEG_APCC_DBOX_1	0.7423
p.H905R	DO228338	MALY	ICGC	TRLSLEGLP	DEG_APCC_DBOX_1	0.1667
p.E896K	DO222402	MELA	ICGC	TRLSLEGLP	DEG_APCC_DBOX_1	0.591
p.Y907N	DO49141	PACA	ICGC	TRLSLEGLP	DEG_APCC_DBOX_1	0.1111
p.E906D	DO229208	THCA	ICGC	TRLSLEGLP	DEG_APCC_DBOX_1	0.1389
p.R892C	DO229216	THCA	ICGC	TRLSLEGLP	DEG_APCC_DBOX_1	0.8301
p.M904I	ACH-000317	Kidney Cancer	CCLE	TRLSLEGLP	DEG_APCC_DBOX_1	0.1944
p.G897E	ACH-000710	Lung Cancer	CCLE	TRLSLEGLP	DEG_APCC_DBOX_1	0.6087
p.S900T	ACH-001495	Endometrial/Uterine Cancer	CCLE	TRLSLEGLP	DEG_APCC_DBOX_1	0.3056
p.R886Q	ACH-001652	Endometrial/Uterine Cancer	CCLE	TRLSLEGLP	DEG_APCC_DBOX_1	0.1944
p.M904V	ACH-002048	Sarcoma	CCLE	TRLSLEGLP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4H2	Insulin receptor substrate 2	DEG_APCC_DBOX_1	891:899	TRLSLEGLP	APC,CDC20,FZR1	0.822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons