DegronMD - Q9C0C2(TNKS1BP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1035L	TCGA-17-Z028	LUAD	TCGA	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation altering degron motif	0.6765
p.S1047I	TCGA-19-5956	GBM	TCGA	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation blocking phosphorylation signal	0.5556
p.S1047I	DO13863	GBM	ICGC	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation blocking phosphorylation signal	0.5556
p.L685P	TCGA-55-1594	LUAD	TCGA	PESSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.25
p.L685P	DO24722	LUAD	ICGC	PESSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.25
p.L84P	TCGA-5M-AAT6	COAD	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1111
p.L84P	DO223703	COAD	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1111
p.P68T	TCGA-66-2781	LUSC	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.5919
p.P68T	DO26422	LUSC	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.5919
p.L75F	TCGA-75-6214	LUAD	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.6981
p.L75F	DO24830	LUAD	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.6981
p.P676A	TCGA-90-7964	LUSC	TCGA	PESSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.2778
p.P676A	DO27046	LUSC	ICGC	PESSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.2778
p.K1466N	TCGA-A5-A0G2	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.3056
p.K1466N	DO41235	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.3056
p.R66W	TCGA-A8-A095	BRCA	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2778
p.R66W	DO224768	BRCA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2778
p.R66W	DO3940	BRCA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2778
p.F1028L	TCGA-AX-A06F	UCEC	TCGA	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation rewiring degron network	0.3056
p.F1028L	DO41752	UCEC	ICGC	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation rewiring degron network	0.3056
p.S1031G	TCGA-BG-A221	UCEC	TCGA	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation altering degron motif	0.5882
p.S1031G	DO42384	UCEC	ICGC	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation altering degron motif	0.5882
p.P67H	TCGA-CG-4306	STAD	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.3056
p.P67H	DO38567	STAD	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.3056
p.G1025R	TCGA-CG-4460	STAD	TCGA	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation rewiring degron network	0.2222
p.G1025R	DO233267	GACA	ICGC	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation rewiring degron network	0.2222
p.G1025R	DO38427	STAD	ICGC	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation rewiring degron network	0.2222
p.R69L	TCGA-D3-A2JD	SKCM	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.8428
p.R69L	TCGA-EE-A2GO	SKCM	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.8428
p.R69L	DO37543	SKCM	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.8428
p.R69L	DO37823	SKCM	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.8428
p.P62L	TCGA-EE-A2MI	SKCM	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1667
p.P62L	DO37531	SKCM	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1667
p.K1466M	TCGA-F4-6459	COAD	TCGA	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.3056
p.K1466M	DO7843	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.3056
p.P676S	TCGA-FW-A3R5	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.2778
p.P676S	DO37406	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.2778
p.D1037H	TCGA-H4-A2HO	BLCA	TCGA	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation altering degron motif	0.7688
p.D1037H	DO494	BLCA	ICGC	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation altering degron motif	0.7688
p.P68S	TCGA-LT-A5Z6	BLCA	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.5641
p.P68S	TCGA-QB-AA9O	SKCM	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.5641
p.P68S	DO44029	BLCA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.5641
p.P68S	DO220877	MELA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.5641
p.P68S	DO51267	SKCM	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.5641
p.D1044Y	TCGA-ND-A4WC	UCS	TCGA	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation rewiring degron network	0.1944
p.N82K	DO228971	LICA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1667
p.D686E	DO228985	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.2222
p.E674Q	DO50824	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.2222
p.E1021G	DO50825	LIRI	ICGC	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation rewiring degron network	0.1111
p.P68L	DO222837	MELA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.6471
p.P68L	DO218847	SKCA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.6471
p.P76L	DO222908	MELA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.6471
p.P71L	DO222908	MELA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.6471
p.G1451S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.0556
p.G1451S	SIDM00846	Cervical Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.0556
p.G1451S	SIDM00721	Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.0556
p.G1451S	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.0556
p.E674K	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	PESSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.2222
p.A78S	SIDM00545	Melanoma	GDSC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2778
p.A78S	ACH-000987	Skin Cancer	CCLE	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2778
p.A78S	Mewo	skin	COSMIC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2778
p.G70D	SIDM00652	Small Cell Lung Carcinoma	GDSC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.6087
p.G70D	ACH-000780	Lung Cancer	CCLE	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.6087
p.G70D	NCI-H1105	lung	COSMIC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.6087
p.V61M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1389
p.V61M	ACH-002256	Leukemia	CCLE	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1389
p.V61M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1389
p.S1463I	SIDM00968	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation altering degron motif	0.8453
p.S1463I	ACH-000542	Ovarian Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation altering degron motif	0.8453
p.S1463I	ACH-002140	Ovarian Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation altering degron motif	0.8453
p.S1463I	Hey	ovary	COSMIC	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation altering degron motif	0.8453
p.R1470Q	SIDM01086	B-Lymphoblastic Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.1944
p.R1470Q	ACH-000874	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.1944
p.R1470Q	RS4-11	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.1944
p.V1035M	SIDM01617	Endometrial Carcinoma	GDSC	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation altering degron motif	0.7208
p.V1035M	ACH-000994	Endometrial/Uterine Cancer	CCLE	SPSTAHVPDGA	DEG_COP1_1	1029:1039	Mutation altering degron motif	0.7208
p.A1467V	ACH-000971	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1461:1465	Mutation rewiring degron network	0.2778
p.G70A	ACH-001064	Lymphoma	CCLE	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.6429
p.G70A	EB2	haematopoietic and lymphoid tissue	COSMIC	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.6429
p.M81I	ACH-001402	Cervical Cancer	CCLE	PRGPLAELP	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNKS1BP1

UniProt ID: Q9C0C2

Entrez ID: 85456

Protein name: 182 kDa tankyrase-1-binding protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNKS1BP1 in