DegronMD

Uniprot ID: Q9C0C2

Source protein: 182 kDa tankyrase-1-binding protein

Source gene: TNKS1BP1

Class: DEG_COP1_1

Location: 1029:1039

E3 ligase: COP1

DEGRON score: 0.998

ASA_SCORE: 68.4364

COIL: 0.8736

CONS_SCORE: 0.6365

DSS_SCORE: 0.7225

HELIX: 0.055

FCONS_SCORE: 1.0968

RIG_SCORE: 0.6441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1035L	TCGA-17-Z028	LUAD	TCGA	SPSTAHVPDGA	DEG_COP1_1	0.6765
p.S1047I	TCGA-19-5956	GBM	TCGA	SPSTAHVPDGA	DEG_COP1_1	0.5556
p.S1047I	DO13863	GBM	ICGC	SPSTAHVPDGA	DEG_COP1_1	0.5556
p.F1028L	TCGA-AX-A06F	UCEC	TCGA	SPSTAHVPDGA	DEG_COP1_1	0.3056
p.F1028L	DO41752	UCEC	ICGC	SPSTAHVPDGA	DEG_COP1_1	0.3056
p.S1031G	TCGA-BG-A221	UCEC	TCGA	SPSTAHVPDGA	DEG_COP1_1	0.5882
p.S1031G	DO42384	UCEC	ICGC	SPSTAHVPDGA	DEG_COP1_1	0.5882
p.G1025R	TCGA-CG-4460	STAD	TCGA	SPSTAHVPDGA	DEG_COP1_1	0.2222
p.G1025R	DO233267	GACA	ICGC	SPSTAHVPDGA	DEG_COP1_1	0.2222
p.G1025R	DO38427	STAD	ICGC	SPSTAHVPDGA	DEG_COP1_1	0.2222
p.D1037H	TCGA-H4-A2HO	BLCA	TCGA	SPSTAHVPDGA	DEG_COP1_1	0.7688
p.D1037H	DO494	BLCA	ICGC	SPSTAHVPDGA	DEG_COP1_1	0.7688
p.D1044Y	TCGA-ND-A4WC	UCS	TCGA	SPSTAHVPDGA	DEG_COP1_1	0.1944
p.E1021G	DO50825	LIRI	ICGC	SPSTAHVPDGA	DEG_COP1_1	0.1111
p.V1035M	SIDM01617	Endometrial Carcinoma	GDSC	SPSTAHVPDGA	DEG_COP1_1	0.7208
p.V1035M	ACH-000994	Endometrial/Uterine Cancer	CCLE	SPSTAHVPDGA	DEG_COP1_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0C2	182 kDa tankyrase-1-binding protein	DEG_COP1_1	1029:1039	SPSTAHVPDGA	COP1	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons