DegronMD

Uniprot ID: Q9C0C2

Source protein: 182 kDa tankyrase-1-binding protein

Source gene: TNKS1BP1

Class: DEG_APCC_DBOX_1

Location: 68:76

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9121

ASA_SCORE: 92.8

COIL: 0.9412

CONS_SCORE: 1

DSS_SCORE: 0.5888

HELIX: 0.0432

FCONS_SCORE: 1.0202

RIG_SCORE: 0.6374

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L84P	TCGA-5M-AAT6	COAD	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	0.1111
p.L84P	DO223703	COAD	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.1111
p.P68T	TCGA-66-2781	LUSC	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	0.5919
p.P68T	DO26422	LUSC	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.5919
p.L75F	TCGA-75-6214	LUAD	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	0.6981
p.L75F	DO24830	LUAD	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.6981
p.R66W	TCGA-A8-A095	BRCA	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	0.2778
p.R66W	DO224768	BRCA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.2778
p.R66W	DO3940	BRCA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.2778
p.P67H	TCGA-CG-4306	STAD	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	0.3056
p.P67H	DO38567	STAD	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.3056
p.R69L	TCGA-D3-A2JD	SKCM	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	0.8428
p.R69L	TCGA-EE-A2GO	SKCM	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	0.8428
p.R69L	DO37543	SKCM	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.8428
p.R69L	DO37823	SKCM	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.8428
p.P62L	TCGA-EE-A2MI	SKCM	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	0.1667
p.P62L	DO37531	SKCM	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.1667
p.P68S	TCGA-LT-A5Z6	BLCA	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	0.5641
p.P68S	TCGA-QB-AA9O	SKCM	TCGA	PRGPLAELP	DEG_APCC_DBOX_1	0.5641
p.P68S	DO44029	BLCA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.5641
p.P68S	DO220877	MELA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.5641
p.P68S	DO51267	SKCM	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.5641
p.N82K	DO228971	LICA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.1667
p.P68L	DO222837	MELA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.6471
p.P68L	DO218847	SKCA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.6471
p.P76L	DO222908	MELA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.6471
p.P71L	DO222908	MELA	ICGC	PRGPLAELP	DEG_APCC_DBOX_1	0.6471
p.A78S	SIDM00545	Melanoma	GDSC	PRGPLAELP	DEG_APCC_DBOX_1	0.2778
p.A78S	ACH-000987	Skin Cancer	CCLE	PRGPLAELP	DEG_APCC_DBOX_1	0.2778
p.A78S	Mewo	skin	COSMIC	PRGPLAELP	DEG_APCC_DBOX_1	0.2778
p.G70D	SIDM00652	Small Cell Lung Carcinoma	GDSC	PRGPLAELP	DEG_APCC_DBOX_1	0.6087
p.G70D	ACH-000780	Lung Cancer	CCLE	PRGPLAELP	DEG_APCC_DBOX_1	0.6087
p.G70D	NCI-H1105	lung	COSMIC	PRGPLAELP	DEG_APCC_DBOX_1	0.6087
p.V61M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PRGPLAELP	DEG_APCC_DBOX_1	0.1389
p.V61M	ACH-002256	Leukemia	CCLE	PRGPLAELP	DEG_APCC_DBOX_1	0.1389
p.V61M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PRGPLAELP	DEG_APCC_DBOX_1	0.1389
p.G70A	ACH-001064	Lymphoma	CCLE	PRGPLAELP	DEG_APCC_DBOX_1	0.6429
p.G70A	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	PRGPLAELP	DEG_APCC_DBOX_1	0.6429
p.M81I	ACH-001402	Cervical Cancer	CCLE	PRGPLAELP	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRGPLAELP

Degron related mutations and impact score

Drug responses associated with TNKS1BP1 mutations

All proteins holding degron of PRGPLAELP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0C2	182 kDa tankyrase-1-binding protein	DEG_APCC_DBOX_1	68:76	PRGPLAELP	APC,CDC20,FZR1	0.9121	More...