DegronMD - Q92574(TSC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E636K	TCGA-2W-A8YY	CESC	TCGA	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.2222
p.E636K	DO223732	CESC	ICGC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.2222
p.G528D	TCGA-4Z-AA80	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.2778
p.G528D	DO218986	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.2778
p.A529S	TCGA-50-5941	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.25
p.A529S	DO25528	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.25
p.A529V	TCGA-AP-A051	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.25
p.A529V	DO42673	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.25
p.G378A	TCGA-AR-A24Q	BRCA	TCGA	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.0833
p.G378A	DO3524	BRCA	ICGC	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.0833
p.P533H	TCGA-B5-A3FC	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1389
p.P533H	DO41871	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1389
p.S403L	TCGA-BK-A6W3	UCEC	TCGA	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.0833
p.S403L	DO50076	UCEC	ICGC	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.0833
p.G382D	TCGA-BR-A4QL	STAD	TCGA	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.1944
p.G382D	DO38723	STAD	ICGC	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.1944
p.S361Y	TCGA-BS-A0UV	UCEC	TCGA	MTTPPTS	DEG_SCF_FBW7_1	355:361	Mutation altering degron motif	0.712
p.S361Y	DO42793	UCEC	ICGC	MTTPPTS	DEG_SCF_FBW7_1	355:361	Mutation altering degron motif	0.712
p.P535H	TCGA-CG-4460	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.0833
p.P535H	DO38427	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.0833
p.G305W	TCGA-D3-A1Q1	SKCM	TCGA	SRLMLLNMP	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.0556
p.G305W	TCGA-D3-A1Q1	SKCM	TCGA	PYSTS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.1667
p.G305W	TCGA-EE-A183	SKCM	TCGA	SRLMLLNMP	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.0556
p.G305W	TCGA-EE-A183	SKCM	TCGA	PYSTS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.1667
p.G305W	DO37715	SKCM	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.0556
p.G305W	DO37715	SKCM	ICGC	PYSTS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.1667
p.G305W	DO37445	SKCM	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.0556
p.G305W	DO37445	SKCM	ICGC	PYSTS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.1667
p.P591Q	TCGA-D3-A2JL	SKCM	TCGA	PPPY	ITCH	601:604	Mutation rewiring degron network	0.0556
p.P591Q	DO47278	SKCM	ICGC	PPPY	ITCH	601:604	Mutation rewiring degron network	0.0556
p.V531M	TCGA-DW-7840	KIRP	TCGA	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1944
p.V531M	DO20790	KIRP	ICGC	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1944
p.K614N	TCGA-EK-A3GK	CESC	TCGA	PPPY	ITCH	601:604	Mutation substituting flanking lysine	0.1667
p.K614N	DO49964	CESC	ICGC	PPPY	ITCH	601:604	Mutation substituting flanking lysine	0.1667
p.P591L	TCGA-EO-A22U	UCEC	TCGA	PPPY	ITCH	601:604	Mutation rewiring degron network	0.0556
p.P591L	DO43755	UCEC	ICGC	PPPY	ITCH	601:604	Mutation rewiring degron network	0.0556
p.A381S	TCGA-ER-A19N	SKCM	TCGA	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.1667
p.A381S	DO37452	SKCM	ICGC	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.1667
p.P613L	TCGA-FD-A5BU	BLCA	TCGA	PPPY	ITCH	601:604	Mutation rewiring degron network	0.0833
p.P613L	DO44040	BLCA	ICGC	PPPY	ITCH	601:604	Mutation rewiring degron network	0.0833
p.R316Q	TCGA-FI-A2D5	UCEC	TCGA	SRLMLLNMP	DEG_APCC_DBOX_1	315:323	Mutation altering degron motif	0.7329
p.R316Q	DO41331	UCEC	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	315:323	Mutation altering degron motif	0.7329
p.V610A	TCGA-KR-A7K8	LIHC	TCGA	PPPY	ITCH	601:604	Mutation rewiring degron network	0.1667
p.V610A	DO52305	LIHC	ICGC	PPPY	ITCH	601:604	Mutation rewiring degron network	0.1667
p.S361A	TCGA-ZH-A8Y5	CHOL	TCGA	MTTPPTS	DEG_SCF_FBW7_1	355:361	Mutation altering degron motif	0.7588
p.M322T	DO228483	BRCA	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	315:323	Mutation altering degron motif	0.7423
p.M322T	DO229016	COCA	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	315:323	Mutation altering degron motif	0.7423
p.M322T	DO229003	COCA	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	315:323	Mutation altering degron motif	0.7423
p.M322T	DO231075	LUSC	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	315:323	Mutation altering degron motif	0.7423
p.R517Q	DO233766	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1944
p.P613T	DO228937	LICA	ICGC	PPPY	ITCH	601:604	Mutation rewiring degron network	0.0833
p.P359Q	DO228948	LICA	ICGC	MTTPPTS	DEG_SCF_FBW7_1	355:361	Mutation altering degron motif	0.5924
p.S348R	DO229045	LICA	ICGC	MTTPPTS	DEG_SCF_FBW7_1	355:361	Mutation rewiring degron network	0.1389
p.V640M	DO228253	MALY	ICGC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7208
p.Q325K	DO46438	OV	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.2778
p.Q325K	DO46438	OV	ICGC	PYSTS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.0556
p.V365A	DO228645	PRAD	ICGC	MTTPPTS	DEG_SCF_FBW7_1	355:361	Mutation rewiring degron network	0.2222
p.P603L	DO229491	SKCA	ICGC	PPPY	ITCH	601:604	Mutation altering degron motif	0.6471
p.A523T	SIDM00683	Prostate Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	522:526	Mutation altering degron motif	0.6028
p.A523T	ACH-000977	lymph node	CCLE	AASSS	DEG_SPOP_SBC_1	522:526	Mutation altering degron motif	0.6028
p.Q654E	SIDM00367	Small Cell Lung Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.0556
p.Q654E	SIDM00553	Acute Myeloid Leukemia	GDSC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.0556
p.Q654E	SIDM00383	Gastric Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.0556
p.Q654E	SIDM00024	Non-Cancerous	GDSC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.0556
p.Q654E	SIDM00579	Neuroblastoma	GDSC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.0556
p.Q654E	SIDM01442	Glioma	GDSC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.0556
p.G378R	SIDM00932	Kidney Carcinoma	GDSC	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.0833
p.G378R	CAL-54	kidney	COSMIC	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.0833
p.M646V	SIDM00694	Other Solid Cancers	GDSC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.2778
p.M646V	HUTU-80	small intestine	COSMIC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.2778
p.D404Y	SIDM00877	Breast Carcinoma	GDSC	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.0556
p.D404Y	ACH-000196	Breast Cancer	CCLE	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.0556
p.D404Y	HCC1599	breast	COSMIC	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.0556
p.L388P	SIDM01318	Hepatocellular Carcinoma	GDSC	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation altering degron motif	0.6471
p.L388P	ACH-001318	Liver Cancer	CCLE	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation altering degron motif	0.6471
p.G639V	ACH-001029	Bone Cancer	CCLE	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.3056
p.G639V	ACH-001034	Bone Cancer	CCLE	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.3056
p.A529T	ACH-002800	Unknown	CCLE	AASSS	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.25
p.I637F	TE-12	oesophagus	COSMIC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.25
p.Y322C	IM-95	stomach	COSMIC	SRLMLLNMP	DEG_APCC_DBOX_1	315:323	Mutation altering degron motif	0.7087
p.C521Y	SNU-175	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	522:526	Mutation blocking phosphorylation signal	0.75
p.L645F	KON	upper aerodigestive tract	COSMIC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.3056
p.M595V	HUTU-80	small intestine	COSMIC	PPPY	ITCH	601:604	Mutation rewiring degron network	0.1667
p.R641Q	8505C	thyroid	COSMIC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7329
p.D353Y	HCC1599	breast	COSMIC	MTTPPTS	DEG_SCF_FBW7_1	355:361	Mutation rewiring degron network	0.2778
p.G358V	SNU-1040	large intestine	COSMIC	MTTPPTS	DEG_SCF_FBW7_1	355:361	Mutation altering degron motif	0.7532
p.M645V	HUTU-80	small intestine	COSMIC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.3056
p.D404G	RKN	ovary	COSMIC	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.0556
p.D403Y	HCC1599	breast	COSMIC	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.0833
p.G630D	GP5d	large intestine	COSMIC	VPSTS	DEG_SPOP_SBC_1	640:644	Mutation substituting flanking lysine	0.1667
p.G327R	CAL-54	kidney	COSMIC	SRLMLLNMP	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.2222
p.S402F	EN	endometrium	COSMIC	PLGTPATS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.1111
p.D354G	RKN	ovary	COSMIC	MTTPPTS	DEG_SCF_FBW7_1	355:361	Mutation rewiring degron network	0.3056

Kaplan plot for TSC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TSC1

UniProt ID: Q92574

Entrez ID: 7248

Protein name: Hamartin (Tuberous sclerosis 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TSC1 in