DegronMD

Uniprot ID: Q92574

Source protein: Hamartin

Source gene: TSC1

Class: DEG_SCF_FBW7_1

Location: 355:361

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 89.4857

COIL: 0.9751

CONS_SCORE: 0.6654

DSS_SCORE: 0.5749

HELIX: 0.007

FCONS_SCORE: 1.065

RIG_SCORE: 0.6341

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S361Y	TCGA-BS-A0UV	UCEC	TCGA	MTTPPTS	DEG_SCF_FBW7_1	0.712
p.S361Y	DO42793	UCEC	ICGC	MTTPPTS	DEG_SCF_FBW7_1	0.712
p.S361A	TCGA-ZH-A8Y5	CHOL	TCGA	MTTPPTS	DEG_SCF_FBW7_1	0.7588
p.P359Q	DO228948	LICA	ICGC	MTTPPTS	DEG_SCF_FBW7_1	0.5924
p.S348R	DO229045	LICA	ICGC	MTTPPTS	DEG_SCF_FBW7_1	0.1389
p.V365A	DO228645	PRAD	ICGC	MTTPPTS	DEG_SCF_FBW7_1	0.2222
p.D353Y	HCC1599	breast	COSMIC	MTTPPTS	DEG_SCF_FBW7_1	0.2778
p.G358V	SNU-1040	large_intestine	COSMIC	MTTPPTS	DEG_SCF_FBW7_1	0.7532
p.D354G	RKN	ovary	COSMIC	MTTPPTS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92574	Hamartin	DEG_SCF_FBW7_1	355:361	MTTPPTS	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons