DegronMD

Uniprot ID: Q92574

Source protein: Hamartin

Source gene: TSC1

Class: DEG_SCF_FBW7_1

Location: 387:394

E3 ligase: FBXW7

DEGRON score: 0.9906

ASA_SCORE: 76.575

COIL: 0.9049

CONS_SCORE: 0.6208

DSS_SCORE: 0.658

HELIX: 0.0141

FCONS_SCORE: 1.0233

RIG_SCORE: 0.6093

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G378A	TCGA-AR-A24Q	BRCA	TCGA	PLGTPATS	DEG_SCF_FBW7_1	0.0833
p.G378A	DO3524	BRCA	ICGC	PLGTPATS	DEG_SCF_FBW7_1	0.0833
p.S403L	TCGA-BK-A6W3	UCEC	TCGA	PLGTPATS	DEG_SCF_FBW7_1	0.0833
p.S403L	DO50076	UCEC	ICGC	PLGTPATS	DEG_SCF_FBW7_1	0.0833
p.G382D	TCGA-BR-A4QL	STAD	TCGA	PLGTPATS	DEG_SCF_FBW7_1	0.1944
p.G382D	DO38723	STAD	ICGC	PLGTPATS	DEG_SCF_FBW7_1	0.1944
p.A381S	TCGA-ER-A19N	SKCM	TCGA	PLGTPATS	DEG_SCF_FBW7_1	0.1667
p.A381S	DO37452	SKCM	ICGC	PLGTPATS	DEG_SCF_FBW7_1	0.1667
p.G378R	SIDM00932	Kidney Carcinoma	GDSC	PLGTPATS	DEG_SCF_FBW7_1	0.0833
p.G378R	CAL-54	kidney	COSMIC	PLGTPATS	DEG_SCF_FBW7_1	0.0833
p.D404Y	SIDM00877	Breast Carcinoma	GDSC	PLGTPATS	DEG_SCF_FBW7_1	0.0556
p.D404Y	ACH-000196	Breast Cancer	CCLE	PLGTPATS	DEG_SCF_FBW7_1	0.0556
p.D404Y	HCC1599	breast	COSMIC	PLGTPATS	DEG_SCF_FBW7_1	0.0556
p.L388P	SIDM01318	Hepatocellular Carcinoma	GDSC	PLGTPATS	DEG_SCF_FBW7_1	0.6471
p.L388P	ACH-001318	Liver Cancer	CCLE	PLGTPATS	DEG_SCF_FBW7_1	0.6471
p.D404G	RKN	ovary	COSMIC	PLGTPATS	DEG_SCF_FBW7_1	0.0556
p.D403Y	HCC1599	breast	COSMIC	PLGTPATS	DEG_SCF_FBW7_1	0.0833
p.S402F	EN	endometrium	COSMIC	PLGTPATS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92574	Hamartin	DEG_SCF_FBW7_1	387:394	PLGTPATS	FBXW7	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons