DegronMD

Uniprot ID: Q92574

Source protein: Hamartin

Source gene: TSC1

Class: DEG_APCC_DBOX_1

Location: 315:323

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8847

ASA_SCORE: 87.0222

COIL: 0.6289

CONS_SCORE: 0.5916

DSS_SCORE: 0.4723

HELIX: 0.3328

FCONS_SCORE: 0.9781

RIG_SCORE: 0.7778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G305W	TCGA-D3-A1Q1	SKCM	TCGA	SRLMLLNMP	DEG_APCC_DBOX_1	0.0556
p.G305W	TCGA-EE-A183	SKCM	TCGA	SRLMLLNMP	DEG_APCC_DBOX_1	0.0556
p.G305W	DO37715	SKCM	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	0.0556
p.G305W	DO37445	SKCM	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	0.0556
p.R316Q	TCGA-FI-A2D5	UCEC	TCGA	SRLMLLNMP	DEG_APCC_DBOX_1	0.7329
p.R316Q	DO41331	UCEC	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	0.7329
p.M322T	DO228483	BRCA	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	0.7423
p.M322T	DO229016	COCA	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	0.7423
p.M322T	DO229003	COCA	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	0.7423
p.M322T	DO231075	LUSC	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	0.7423
p.Q325K	DO46438	OV	ICGC	SRLMLLNMP	DEG_APCC_DBOX_1	0.2778
p.Y322C	IM-95	stomach	COSMIC	SRLMLLNMP	DEG_APCC_DBOX_1	0.7087
p.G327R	CAL-54	kidney	COSMIC	SRLMLLNMP	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92574	Hamartin	DEG_APCC_DBOX_1	315:323	SRLMLLNMP	APC,CDC20,FZR1	0.8847	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons