DegronMD

Uniprot ID: Q92574

Source protein: Hamartin

Source gene: TSC1

Class: DEG_SPOP_SBC_1

Location: 311:315

E3 ligase: SPOP

DEGRON score: 0.9976

ASA_SCORE: 81.28

COIL: 0.7392

CONS_SCORE: 0.6502

DSS_SCORE: 0.3902

HELIX: 0.2268

FCONS_SCORE: 1.1001

RIG_SCORE: 0.7718

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G305W	TCGA-D3-A1Q1	SKCM	TCGA	PYSTS	DEG_SPOP_SBC_1	0.1667
p.G305W	TCGA-EE-A183	SKCM	TCGA	PYSTS	DEG_SPOP_SBC_1	0.1667
p.G305W	DO37715	SKCM	ICGC	PYSTS	DEG_SPOP_SBC_1	0.1667
p.G305W	DO37445	SKCM	ICGC	PYSTS	DEG_SPOP_SBC_1	0.1667
p.Q325K	DO46438	OV	ICGC	PYSTS	DEG_SPOP_SBC_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons