DegronMD - Q9NY43(BARHL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P184Q	TCGA-18-4083	LUSC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.0556
p.P184Q	DO26504	LUSC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.0556
p.L154V	TCGA-77-7337	LUSC	TCGA	PYSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1944
p.L154V	DO27445	LUSC	ICGC	PYSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1944
p.P184T	TCGA-A5-A1OF	UCEC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.0556
p.P184T	DO228952	LICA	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.0556
p.P184T	DO42568	UCEC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.0556
p.A177T	TCGA-AJ-A8CW	UCEC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.25
p.A177T	TCGA-B5-A3FA	UCEC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.25
p.A177T	DO52400	UCEC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.25
p.A177T	DO52402	UCEC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.25
p.P171L	TCGA-B7-A5TI	STAD	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.7582
p.P171L	DO222328	STAD	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.7582
p.S175I	TCGA-DF-A2KZ	UCEC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.3056
p.S175I	DO52409	UCEC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.3056
p.P167H	TCGA-EE-A2GL	SKCM	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.7694
p.P167H	DO37434	SKCM	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.7694
p.L143F	TCGA-EI-6512	READ	TCGA	PRTST	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2222
p.L143F	DO36455	READ	ICGC	PRTST	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2222
p.E180D	TCGA-F5-6814	READ	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.1667
p.E180D	DO36556	READ	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.1667
p.A158T	TCGA-FI-A2D5	UCEC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.0833
p.A158T	TCGA-FI-A2D5	UCEC	TCGA	PYSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.A158T	DO41331	UCEC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.0833
p.A158T	DO41331	UCEC	ICGC	PYSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.T162I	TCGA-FU-A23K	CESC	TCGA	PYSTS	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.7078
p.T162I	DO6305	CESC	ICGC	PYSTS	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.7078
p.F182V	DO234412	ESAD	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.1111
p.A132T	DO233156	GACA	ICGC	PRTST	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.25
p.A155V	DO233242	GACA	ICGC	PYSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2222
p.S133P	DO233903	GACA	ICGC	PRTST	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2778
p.N176K	DO228952	LICA	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.2778
p.L148F	DO26427	LUSC	ICGC	PRTST	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0833
p.S140F	DO34921	PACA	ICGC	PRTST	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.3056
p.H168N	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.6312
p.H168N	ACH-002272	Lymphoma	CCLE	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.6312
p.H168N	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.6312
p.A131D	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2222
p.A131D	ACH-000434	Lung Cancer	CCLE	PRTST	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2222
p.K145N	ACH-001228		CCLE	PRTST	DEG_SPOP_SBC_1	135:139	Mutation substituting flanking lysine	0.2778

Kaplan plot for BARHL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BARHL2

UniProt ID: Q9NY43

Entrez ID: 343472

Protein name: BarH-like 2 homeobox protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BARHL2 in