DegronMD - Q9NY43(BARHL2)

FUNCTION: Potential regulator of neural basic helix-loop-helix genes. {ECO:0000250}.

GO - Biological processes (BP): cell fate determination [GO:0001709]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; positive regulation of translation [GO:0045727]; regulation of axon extension [GO:0030516]; regulation of transcription by RNA polymerase II [GO:0006357]

GO - Molecular function (MF): DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded D... View more >>

GO - Cellular component (CC): chromatin [GO:0000785]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P167H	TCGA-EE-A2GL	SKCM	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.7694
p.P167H	DO37434	SKCM	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.7694
p.P171L	TCGA-B7-A5TI	STAD	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.7582
p.P171L	DO222328	STAD	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.7582
p.T162I	TCGA-FU-A23K	CESC	TCGA	PYSTS	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.7078
p.T162I	DO6305	CESC	ICGC	PYSTS	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.7078
p.H168N	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.6312
p.H168N	ACH-002272	Lymphoma	CCLE	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.6312
p.H168N	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation altering degron motif	0.6312
p.S175I	TCGA-DF-A2KZ	UCEC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.3056
p.S175I	DO52409	UCEC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.3056
p.A158T	TCGA-FI-A2D5	UCEC	TCGA	PYSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.A158T	DO41331	UCEC	ICGC	PYSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.S140F	DO34921	PACA	ICGC	PRTST	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.3056
p.S133P	DO233903	GACA	ICGC	PRTST	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2778
p.N176K	DO228952	LICA	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.2778
p.K145N	ACH-001228		CCLE	PRTST	DEG_SPOP_SBC_1	135:139	Mutation substituting flanking lysine	0.2778
p.A177T	TCGA-AJ-A8CW	UCEC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.25
p.A177T	TCGA-B5-A3FA	UCEC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.25
p.A177T	DO52400	UCEC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	167:174	Mutation rewiring degron network	0.25

Showing 1 to 20 of 40 entries

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Kaplan plot for BARHL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BARHL2

UniProt ID: Q9NY43

Entrez ID: 343472

Protein name: BarH-like 2 homeobox protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BARHL2 in