DegronMD

Uniprot ID: Q9NY43

Source protein: BarH-like 2 homeobox protein

Source gene: BARHL2

Class: DEG_SPOP_SBC_1

Location: 135:139

E3 ligase: SPOP

DEGRON score: 0.77

ASA_SCORE: 99.16

COIL: 0.9276

CONS_SCORE: 0.4125

DSS_SCORE: 0.5939

HELIX: 0.0416

FCONS_SCORE: 1.0389

RIG_SCORE: 0.6213

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L143F	TCGA-EI-6512	READ	TCGA	PRTST	DEG_SPOP_SBC_1	0.2222
p.L143F	DO36455	READ	ICGC	PRTST	DEG_SPOP_SBC_1	0.2222
p.A132T	DO233156	GACA	ICGC	PRTST	DEG_SPOP_SBC_1	0.25
p.S133P	DO233903	GACA	ICGC	PRTST	DEG_SPOP_SBC_1	0.2778
p.L148F	DO26427	LUSC	ICGC	PRTST	DEG_SPOP_SBC_1	0.0833
p.S140F	DO34921	PACA	ICGC	PRTST	DEG_SPOP_SBC_1	0.3056
p.A131D	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	0.2222
p.A131D	ACH-000434	Lung Cancer	CCLE	PRTST	DEG_SPOP_SBC_1	0.2222
p.K145N	ACH-001228		CCLE	PRTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3168:3172	PRTST	SPOP	0.987	More...
Q6P2H3	Centrosomal protein of 85 kDa	DEG_SPOP_SBC_1	210:214	PRTST	SPOP	0.9974	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	289:293	PRTST	SPOP	0.9967	More...
Q8TAP9	M-phase-specific PLK1-interacting protein	DEG_SPOP_SBC_1	116:120	PRTST	SPOP	0.9988	More...
Q96C45	Serine/threonine-protein kinase ULK4	DEG_SPOP_SBC_1	367:371	PRTST	SPOP	0.8239	More...
Q9NZN5	Rho guanine nucleotide exchange factor 12	DEG_SPOP_SBC_1	1328:1332	PRTST	SPOP	0.9959	More...
Q9NY43	BarH-like 2 homeobox protein	DEG_SPOP_SBC_1	135:139	PRTST	SPOP	0.77	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1789:1793	PRTST	SPOP	0.7676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons