DegronMD

Uniprot ID: Q8TAP9

Source protein: M-phase-specific PLK1-interacting protein

Source gene: MPLKIP

Class: DEG_SPOP_SBC_1

Location: 116:120

E3 ligase: SPOP

DEGRON score: 0.9988

ASA_SCORE: 76.32

COIL: 0.8742

CONS_SCORE: 1

DSS_SCORE: 0.8374

HELIX: 0.0174

FCONS_SCORE: 1.3563

RIG_SCORE: 0.5559

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G123E	TCGA-86-7955	LUAD	TCGA	PRTST	DEG_SPOP_SBC_1	0.25
p.G123E	DO23612	LUAD	ICGC	PRTST	DEG_SPOP_SBC_1	0.25
p.R126H	TCGA-AA-3663	COAD	TCGA	PRTST	DEG_SPOP_SBC_1	0.1667
p.R126H	DO9346	COAD	ICGC	PRTST	DEG_SPOP_SBC_1	0.1667
p.R126C	TCGA-AX-A1CE	UCEC	TCGA	PRTST	DEG_SPOP_SBC_1	0.1667
p.R126C	DO234353	ESAD	ICGC	PRTST	DEG_SPOP_SBC_1	0.1667
p.R126C	DO42280	UCEC	ICGC	PRTST	DEG_SPOP_SBC_1	0.1667
p.R128T	DO223079	ESCA	ICGC	PRTST	DEG_SPOP_SBC_1	0.1111
p.T120K	DO228938	LICA	ICGC	PRTST	DEG_SPOP_SBC_1	0.8417
p.P116Q	DO229032	LICA	ICGC	PRTST	DEG_SPOP_SBC_1	0.7035
p.S119C	DO47147	RECA	ICGC	PRTST	DEG_SPOP_SBC_1	0.8652
p.V127G	SIDM00845	Burkitt's Lymphoma	GDSC	PRTST	DEG_SPOP_SBC_1	0.1389
p.V127G	SIDM00461	Acute Myeloid Leukemia	GDSC	PRTST	DEG_SPOP_SBC_1	0.1389
p.V127G	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PRTST	DEG_SPOP_SBC_1	0.1389
p.V127G	SIDM01519	Head and Neck Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	0.1389
p.V127G	ACH-000786	Lymphoma	CCLE	PRTST	DEG_SPOP_SBC_1	0.1389
p.V127G	ACH-000992	Head and Neck Cancer	CCLE	PRTST	DEG_SPOP_SBC_1	0.1389
p.V127G	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PRTST	DEG_SPOP_SBC_1	0.1389
p.V127G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PRTST	DEG_SPOP_SBC_1	0.1389
p.V127G	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PRTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3168:3172	PRTST	SPOP	0.987	More...
Q6P2H3	Centrosomal protein of 85 kDa	DEG_SPOP_SBC_1	210:214	PRTST	SPOP	0.9974	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	289:293	PRTST	SPOP	0.9967	More...
Q8TAP9	M-phase-specific PLK1-interacting protein	DEG_SPOP_SBC_1	116:120	PRTST	SPOP	0.9988	More...
Q96C45	Serine/threonine-protein kinase ULK4	DEG_SPOP_SBC_1	367:371	PRTST	SPOP	0.8239	More...
Q9NZN5	Rho guanine nucleotide exchange factor 12	DEG_SPOP_SBC_1	1328:1332	PRTST	SPOP	0.9959	More...
Q9NY43	BarH-like 2 homeobox protein	DEG_SPOP_SBC_1	135:139	PRTST	SPOP	0.77	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1789:1793	PRTST	SPOP	0.7676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons