DegronMD

Uniprot ID: Q6P2H3

Source protein: Centrosomal protein of 85 kDa

Source gene: CEP85

Class: DEG_SPOP_SBC_1

Location: 210:214

E3 ligase: SPOP

DEGRON score: 0.9974

ASA_SCORE: 87.64

COIL: 0.8644

CONS_SCORE: 0.6734

DSS_SCORE: 0.5509

HELIX: 0.1156

FCONS_SCORE: 0.9857

RIG_SCORE: 0.6605

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S215N	TCGA-BR-4280	STAD	TCGA	PRTST	DEG_SPOP_SBC_1	0.75
p.S215N	DO38663	STAD	ICGC	PRTST	DEG_SPOP_SBC_1	0.75
p.Y219C	TCGA-CG-5721	STAD	TCGA	PRTST	DEG_SPOP_SBC_1	0.6389
p.Y219C	DO38192	STAD	ICGC	PRTST	DEG_SPOP_SBC_1	0.6389
p.H203Y	TCGA-GN-A4U3	SKCM	TCGA	PRTST	DEG_SPOP_SBC_1	0.1389
p.H203Y	DO219484	SKCM	ICGC	PRTST	DEG_SPOP_SBC_1	0.1389
p.S213N	DO228483	BRCA	ICGC	PRTST	DEG_SPOP_SBC_1	0.7069
p.S213N	DO230334	COCA	ICGC	PRTST	DEG_SPOP_SBC_1	0.7069
p.S213N	DO229010	COCA	ICGC	PRTST	DEG_SPOP_SBC_1	0.7069
p.S213N	DO229016	COCA	ICGC	PRTST	DEG_SPOP_SBC_1	0.7069
p.S213N	DO229005	COCA	ICGC	PRTST	DEG_SPOP_SBC_1	0.7069
p.S213N	DO229346	LAML	ICGC	PRTST	DEG_SPOP_SBC_1	0.7069
p.S213N	DO230659	LAML	ICGC	PRTST	DEG_SPOP_SBC_1	0.7069
p.S213N	DO225404	LAML	ICGC	PRTST	DEG_SPOP_SBC_1	0.7069
p.S213N	DO231140	LAML	ICGC	PRTST	DEG_SPOP_SBC_1	0.7069
p.S213N	DO229047	LICA	ICGC	PRTST	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3168:3172	PRTST	SPOP	0.987	More...
Q6P2H3	Centrosomal protein of 85 kDa	DEG_SPOP_SBC_1	210:214	PRTST	SPOP	0.9974	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	289:293	PRTST	SPOP	0.9967	More...
Q8TAP9	M-phase-specific PLK1-interacting protein	DEG_SPOP_SBC_1	116:120	PRTST	SPOP	0.9988	More...
Q96C45	Serine/threonine-protein kinase ULK4	DEG_SPOP_SBC_1	367:371	PRTST	SPOP	0.8239	More...
Q9NZN5	Rho guanine nucleotide exchange factor 12	DEG_SPOP_SBC_1	1328:1332	PRTST	SPOP	0.9959	More...
Q9NY43	BarH-like 2 homeobox protein	DEG_SPOP_SBC_1	135:139	PRTST	SPOP	0.77	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1789:1793	PRTST	SPOP	0.7676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons