DegronMD

Uniprot ID: Q9NZN5

Source protein: Rho guanine nucleotide exchange factor 12

Source gene: ARHGEF12

Class: DEG_SPOP_SBC_1

Location: 1328:1332

E3 ligase: SPOP

DEGRON score: 0.9959

ASA_SCORE: 87.86

COIL: 0.8886

CONS_SCORE: 0.3202

DSS_SCORE: 0.5092

HELIX: 0.0672

FCONS_SCORE: 1.036

RIG_SCORE: 0.7125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1338L	TCGA-95-7039	LUAD	TCGA	PRTST	DEG_SPOP_SBC_1	0.1667
p.R1329Q	TCGA-BR-8487	STAD	TCGA	PRTST	DEG_SPOP_SBC_1	0.6218
p.R1329Q	TCGA-CN-5356	HNSC	TCGA	PRTST	DEG_SPOP_SBC_1	0.6218
p.D1321G	TCGA-EY-A5W2	UCEC	TCGA	PRTST	DEG_SPOP_SBC_1	0.1389
p.R1329L	TCGA-FS-A1ZB	SKCM	TCGA	PRTST	DEG_SPOP_SBC_1	0.7316
p.G1318R	TCGA-HQ-A5NE	BLCA	TCGA	PRTST	DEG_SPOP_SBC_1	0.0556
p.M1342I	DO229018	LICA	ICGC	PRTST	DEG_SPOP_SBC_1	0.0556
p.R1319L	DO23907	LUAD	ICGC	PRTST	DEG_SPOP_SBC_1	0.0833
p.T1324S	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	0.6667
p.T1324S	ACH-000784	Esophageal Cancer	CCLE	PRTST	DEG_SPOP_SBC_1	0.6667
p.T1324S	KYSE-70	oesophagus	COSMIC	PRTST	DEG_SPOP_SBC_1	0.6667
p.Y1318H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PRTST	DEG_SPOP_SBC_1	0.0556
p.T1335S	SNU-449	liver	COSMIC	PRTST	DEG_SPOP_SBC_1	0.25
p.M1339T	GP5d	large_intestine	COSMIC	PRTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3168:3172	PRTST	SPOP	0.987	More...
Q6P2H3	Centrosomal protein of 85 kDa	DEG_SPOP_SBC_1	210:214	PRTST	SPOP	0.9974	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	289:293	PRTST	SPOP	0.9967	More...
Q8TAP9	M-phase-specific PLK1-interacting protein	DEG_SPOP_SBC_1	116:120	PRTST	SPOP	0.9988	More...
Q96C45	Serine/threonine-protein kinase ULK4	DEG_SPOP_SBC_1	367:371	PRTST	SPOP	0.8239	More...
Q9NZN5	Rho guanine nucleotide exchange factor 12	DEG_SPOP_SBC_1	1328:1332	PRTST	SPOP	0.9959	More...
Q9NY43	BarH-like 2 homeobox protein	DEG_SPOP_SBC_1	135:139	PRTST	SPOP	0.77	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1789:1793	PRTST	SPOP	0.7676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons