DegronMD - Q9NZN5(ARHGEF12)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1338L	TCGA-95-7039	LUAD	TCGA	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.1944
p.R1338L	TCGA-95-7039	LUAD	TCGA	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.1667
p.E1364D	TCGA-AP-A0LM	UCEC	TCGA	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.1111
p.E1364D	TCGA-EO-A3B0	UCEC	TCGA	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.1111
p.R1329Q	TCGA-BR-8487	STAD	TCGA	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6218
p.R1329Q	TCGA-CN-5356	HNSC	TCGA	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6218
p.M1365I	TCGA-BR-8680	STAD	TCGA	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.0833
p.D1321G	TCGA-EY-A5W2	UCEC	TCGA	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.1389
p.R1329L	TCGA-FS-A1ZB	SKCM	TCGA	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.7316
p.G1318R	TCGA-HQ-A5NE	BLCA	TCGA	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.0556
p.D1364V	DO3715	BRCA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.1111
p.M1346I	DO222427	BTCA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation altering degron motif	0.7618
p.M1346I	DO47769	STAD	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation altering degron motif	0.7618
p.R1366C	DO233269	GACA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.0556
p.R1366C	DO48009	STAD	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.0556
p.R1366C	EW-7	bone	COSMIC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.0556
p.M1342I	DO229018	LICA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.3056
p.M1342I	DO229018	LICA	ICGC	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.0556
p.R1319L	DO23907	LUAD	ICGC	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.0833
p.D1357H	DO27341	LUSC	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.3056
p.D1356H	DO50712	ORCA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation altering degron motif	0.7688
p.M1349I	DO33016	PACA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation altering degron motif	0.7618
p.A1365D	DO229257	THCA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.0833
p.E1345D	DO219773	UCEC	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation altering degron motif	0.6758
p.E1345D	DO43306	UCEC	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation altering degron motif	0.6758
p.T1324S	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation blocking phosphorylation signal	0.6667
p.T1324S	ACH-000784	Esophageal Cancer	CCLE	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation blocking phosphorylation signal	0.6667
p.T1324S	KYSE-70	oesophagus	COSMIC	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation blocking phosphorylation signal	0.6667
p.Y1318H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.0556
p.T1335S	SNU-449	liver	COSMIC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.1111
p.T1335S	SNU-449	liver	COSMIC	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.25
p.M1339T	GP5d	large intestine	COSMIC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.2222
p.M1339T	GP5d	large intestine	COSMIC	PRTST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.1389
p.A1363V	SNU-1040	large intestine	COSMIC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	1343:1356	Mutation rewiring degron network	0.1389

Kaplan plot for ARHGEF12 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF12

UniProt ID: Q9NZN5

Entrez ID: 23365

Protein name: Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ARHGEF12 in