DegronMD

Uniprot ID: Q9NZN5

Source protein: Rho guanine nucleotide exchange factor 12

Source gene: ARHGEF12

Class: DEG_ODPH_VHL_1

Location: 1343:1356

E3 ligase: VHL

DEGRON score: 0.6927

ASA_SCORE: 86.6786

COIL: 0.7301

CONS_SCORE: 0.3244

DSS_SCORE: 0.5273

HELIX: 0.1881

FCONS_SCORE: 1.0548

RIG_SCORE: 0.7141

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1338L	TCGA-95-7039	LUAD	TCGA	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.1944
p.E1364D	TCGA-AP-A0LM	UCEC	TCGA	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.1111
p.E1364D	TCGA-EO-A3B0	UCEC	TCGA	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.1111
p.M1365I	TCGA-BR-8680	STAD	TCGA	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.0833
p.D1364V	DO3715	BRCA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.1111
p.M1346I	DO222427	BTCA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.7618
p.M1346I	DO47769	STAD	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.7618
p.R1366C	DO233269	GACA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.0556
p.R1366C	DO48009	STAD	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.0556
p.R1366C	EW-7	bone	COSMIC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.0556
p.M1342I	DO229018	LICA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.3056
p.D1357H	DO27341	LUSC	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.3056
p.D1356H	DO50712	ORCA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.7688
p.M1349I	DO33016	PACA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.7618
p.A1365D	DO229257	THCA	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.0833
p.E1345D	DO219773	UCEC	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.6758
p.E1345D	DO43306	UCEC	ICGC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.6758
p.T1335S	SNU-449	liver	COSMIC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.1111
p.M1339T	GP5d	large_intestine	COSMIC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.2222
p.A1363V	SNU-1040	large_intestine	COSMIC	LAPQDSQASNILVM	DEG_ODPH_VHL_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZN5	Rho guanine nucleotide exchange factor 12	DEG_ODPH_VHL_1	1343:1356	LAPQDSQASNILVM	VHL	0.6927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons