DegronMD - Q8TAP9(MPLKIP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G123E	TCGA-86-7955	LUAD	TCGA	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.25
p.G123E	DO23612	LUAD	ICGC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.25
p.R126H	TCGA-AA-3663	COAD	TCGA	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1667
p.R126H	DO9346	COAD	ICGC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1667
p.R126C	TCGA-AX-A1CE	UCEC	TCGA	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1667
p.R126C	DO234353	ESAD	ICGC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1667
p.R126C	DO42280	UCEC	ICGC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1667
p.R128T	DO223079	ESCA	ICGC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1111
p.T120K	DO228938	LICA	ICGC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation altering degron motif	0.8417
p.P116Q	DO229032	LICA	ICGC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation altering degron motif	0.7035
p.S119C	DO47147	RECA	ICGC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation altering degron motif	0.8652
p.V127G	SIDM00845	Burkitt's Lymphoma	GDSC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.V127G	SIDM00461	Acute Myeloid Leukemia	GDSC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.V127G	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.V127G	SIDM01519	Head and Neck Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.V127G	ACH-000786	Lymphoma	CCLE	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.V127G	ACH-000992	Head and Neck Cancer	CCLE	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.V127G	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.V127G	Daudi	haematopoietic and lymphoid tissue	COSMIC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.V127G	DND-41	haematopoietic and lymphoid tissue	COSMIC	PRTST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389

Kaplan plot for MPLKIP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MPLKIP

UniProt ID: Q8TAP9

Entrez ID: 136647

Protein name: M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MPLKIP in