DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRTST
Uniprot ID:
P98088
Source protein:
Mucin-5AC
Source gene:
MUC5AC
Class:
DEG_SPOP_SBC_1
Location:
3168:3172
E3 ligase:
SPOP
DEGRON score:
0.987
ASA_SCORE:
109.26
COIL:
0.9512
CONS_SCORE:
0.2538
DSS_SCORE:
0.6469
HELIX:
0.0178
FCONS_SCORE:
0.7943
RIG_SCORE:
0.6608
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MUC5AC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3168:3172
PRTST
SPOP
0.987
More...
Q6P2H3
Centrosomal protein of 85 kDa
DEG_SPOP_SBC_1
210:214
PRTST
SPOP
0.9974
More...
Q8NEV8
Exophilin-5
DEG_SPOP_SBC_1
289:293
PRTST
SPOP
0.9967
More...
Q8TAP9
M-phase-specific PLK1-interacting protein
DEG_SPOP_SBC_1
116:120
PRTST
SPOP
0.9988
More...
Q96C45
Serine/threonine-protein kinase ULK4
DEG_SPOP_SBC_1
367:371
PRTST
SPOP
0.8239
More...
Q9NZN5
Rho guanine nucleotide exchange factor 12
DEG_SPOP_SBC_1
1328:1332
PRTST
SPOP
0.9959
More...
Q9NY43
BarH-like 2 homeobox protein
DEG_SPOP_SBC_1
135:139
PRTST
SPOP
0.77
More...
Q92576
PHD finger protein 3
DEG_SPOP_SBC_1
1789:1793
PRTST
SPOP
0.7676
More...