DegronMD

Uniprot ID: Q8NEV8

Source protein: Exophilin-5

Source gene: EXPH5

Class: DEG_SPOP_SBC_1

Location: 289:293

E3 ligase: SPOP

DEGRON score: 0.9967

ASA_SCORE: 79.5

COIL: 0.7592

CONS_SCORE: 0.8719

DSS_SCORE: 0.3983

HELIX: 0.0398

FCONS_SCORE: 0.896

RIG_SCORE: 0.7687

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F287S	TCGA-25-2401	OV	TCGA	PRTST	DEG_SPOP_SBC_1	0.2778
p.P289A	TCGA-CN-6998	HNSC	TCGA	PRTST	DEG_SPOP_SBC_1	0.6392
p.G283D	TCGA-D3-A8GI	SKCM	TCGA	PRTST	DEG_SPOP_SBC_1	0.1667
p.R301M	TCGA-EE-A2MD	SKCM	TCGA	PRTST	DEG_SPOP_SBC_1	0.1111
p.S300Y	DO222884	COCA	ICGC	PRTST	DEG_SPOP_SBC_1	0.5833
p.G288V	DO10880	GBM	ICGC	PRTST	DEG_SPOP_SBC_1	0.3056
p.G282R	DO44517	KIRP	ICGC	PRTST	DEG_SPOP_SBC_1	0.1389
p.Q295K	DO229045	LICA	ICGC	PRTST	DEG_SPOP_SBC_1	0.7222
p.S281R	DO224724	PACA	ICGC	PRTST	DEG_SPOP_SBC_1	0.1111
p.G298E	DO37831	SKCM	ICGC	PRTST	DEG_SPOP_SBC_1	0.1944
p.G298E	DO47331	SKCM	ICGC	PRTST	DEG_SPOP_SBC_1	0.1944
p.W293C	DO47683	SKCM	ICGC	PRTST	DEG_SPOP_SBC_1	0.7

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3168:3172	PRTST	SPOP	0.987	More...
Q6P2H3	Centrosomal protein of 85 kDa	DEG_SPOP_SBC_1	210:214	PRTST	SPOP	0.9974	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	289:293	PRTST	SPOP	0.9967	More...
Q8TAP9	M-phase-specific PLK1-interacting protein	DEG_SPOP_SBC_1	116:120	PRTST	SPOP	0.9988	More...
Q96C45	Serine/threonine-protein kinase ULK4	DEG_SPOP_SBC_1	367:371	PRTST	SPOP	0.8239	More...
Q9NZN5	Rho guanine nucleotide exchange factor 12	DEG_SPOP_SBC_1	1328:1332	PRTST	SPOP	0.9959	More...
Q9NY43	BarH-like 2 homeobox protein	DEG_SPOP_SBC_1	135:139	PRTST	SPOP	0.77	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1789:1793	PRTST	SPOP	0.7676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons