DegronMD - Q96C45(ULK4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E2Q	TCGA-55-6969	LUAD	TCGA	FILYEE	LIG_APCC_ABBA_1	4:9	Mutation substituting flanking lysine	0.3889
p.E2Q	DO24586	LUAD	ICGC	FILYEE	LIG_APCC_ABBA_1	4:9	Mutation substituting flanking lysine	0.3889
p.S376R	TCGA-AJ-A3EL	UCEC	TCGA	PTPRTS	DEG_SCF_FBW7_1	365:370	Mutation rewiring degron network	0.1667
p.S376R	TCGA-AJ-A3EL	UCEC	TCGA	PRTST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.1944
p.S376R	DO41542	UCEC	ICGC	PTPRTS	DEG_SCF_FBW7_1	365:370	Mutation rewiring degron network	0.1667
p.S376R	DO41542	UCEC	ICGC	PRTST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.1944
p.K15N	TCGA-AP-A056	UCEC	TCGA	FILYEE	LIG_APCC_ABBA_1	4:9	Mutation substituting flanking lysine	0.2778
p.K15N	TCGA-DK-AA71	BLCA	TCGA	FILYEE	LIG_APCC_ABBA_1	4:9	Mutation substituting flanking lysine	0.2778
p.K15N	DO219010	BLCA	ICGC	FILYEE	LIG_APCC_ABBA_1	4:9	Mutation substituting flanking lysine	0.2778
p.K15N	DO43971	UCEC	ICGC	FILYEE	LIG_APCC_ABBA_1	4:9	Mutation substituting flanking lysine	0.2778
p.P365H	TCGA-CV-7415	HNSC	TCGA	PTPRTS	DEG_SCF_FBW7_1	365:370	Mutation altering degron motif	0.7694
p.P365H	DO14926	HNSC	ICGC	PTPRTS	DEG_SCF_FBW7_1	365:370	Mutation altering degron motif	0.7694
p.M381I	TCGA-CV-A45X	HNSC	TCGA	PRTST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.0556
p.M381I	DO52062	HNSC	ICGC	PRTST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.0556
p.P367L	TCGA-EE-A2M5	SKCM	TCGA	PTPRTS	DEG_SCF_FBW7_1	365:370	Mutation altering degron motif	0.7582
p.P367L	TCGA-EE-A2M5	SKCM	TCGA	PRTST	DEG_SPOP_SBC_1	367:371	Mutation altering degron motif	0.7582
p.P367L	DO222423	MELA	ICGC	PTPRTS	DEG_SCF_FBW7_1	365:370	Mutation altering degron motif	0.7582
p.P367L	DO222423	MELA	ICGC	PRTST	DEG_SPOP_SBC_1	367:371	Mutation altering degron motif	0.7582
p.P367L	DO37425	SKCM	ICGC	PTPRTS	DEG_SCF_FBW7_1	365:370	Mutation altering degron motif	0.7582
p.P367L	DO37425	SKCM	ICGC	PRTST	DEG_SPOP_SBC_1	367:371	Mutation altering degron motif	0.7582
p.R364L	TCGA-EJ-5517	PRAD	TCGA	PTPRTS	DEG_SCF_FBW7_1	365:370	Mutation rewiring degron network	0.3056
p.R364L	TCGA-EJ-5517	PRAD	TCGA	PRTST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.25
p.R364L	DO36305	PRAD	ICGC	PTPRTS	DEG_SCF_FBW7_1	365:370	Mutation rewiring degron network	0.3056
p.R364L	DO36305	PRAD	ICGC	PRTST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.25
p.V494A	TCGA-F7-A624	HNSC	TCGA	SRAKLNLLC	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.2222
p.V494A	DO44440	HNSC	ICGC	SRAKLNLLC	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.2222
p.T16N	TCGA-Q1-A73R	CESC	TCGA	FILYEE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.1389
p.T16N	DO49984	CESC	ICGC	FILYEE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.1389
p.G497C	DO229257	THCA	ICGC	SRAKLNLLC	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1389
p.M381V	DO229240	THCA	ICGC	PRTST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.0556
p.S474F	DO43162	UCEC	ICGC	SRAKLNLLC	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1111
p.V18A	SIDM01653	Non-Cancerous	GDSC	FILYEE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.0833
p.V18A	SIDM00207	Glioblastoma	GDSC	FILYEE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.0833
p.V18A	ACH-002230	Brain Cancer	CCLE	FILYEE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.0833
p.V18A	ACH-002351	Non-Cancerous	CCLE	FILYEE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.0833

Kaplan plot for ULK4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ULK4

UniProt ID: Q96C45

Entrez ID: 54986

Protein name: Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ULK4 in