DegronMD

Uniprot ID: Q96C45

Source protein: Serine/threonine-protein kinase ULK4

Source gene: ULK4

Class: DEG_APCC_DBOX_1

Location: 482:490

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6552

ASA_SCORE: 52.3222

COIL: 0.1107

CONS_SCORE: 0.5036

DSS_SCORE: 0.0173

HELIX: 0.8804

FCONS_SCORE: 1.2183

RIG_SCORE: 0.8692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V494A	TCGA-F7-A624	HNSC	TCGA	SRAKLNLLC	DEG_APCC_DBOX_1	0.2222
p.V494A	DO44440	HNSC	ICGC	SRAKLNLLC	DEG_APCC_DBOX_1	0.2222
p.G497C	DO229257	THCA	ICGC	SRAKLNLLC	DEG_APCC_DBOX_1	0.1389
p.S474F	DO43162	UCEC	ICGC	SRAKLNLLC	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96C45	Serine/threonine-protein kinase ULK4	DEG_APCC_DBOX_1	482:490	SRAKLNLLC	APC,CDC20,FZR1	0.6552	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons