DegronMD

Uniprot ID: Q96C45

Source protein: Serine/threonine-protein kinase ULK4

Source gene: ULK4

Class: DEG_SPOP_SBC_1

Location: 367:371

E3 ligase: SPOP

DEGRON score: 0.8239

ASA_SCORE: 96.58

COIL: 0.897

CONS_SCORE: 0.3285

DSS_SCORE: 0.6101

HELIX: 0.0472

FCONS_SCORE: 1.0097

RIG_SCORE: 0.6233

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S376R	TCGA-AJ-A3EL	UCEC	TCGA	PRTST	DEG_SPOP_SBC_1	0.1944
p.S376R	DO41542	UCEC	ICGC	PRTST	DEG_SPOP_SBC_1	0.1944
p.M381I	TCGA-CV-A45X	HNSC	TCGA	PRTST	DEG_SPOP_SBC_1	0.0556
p.M381I	DO52062	HNSC	ICGC	PRTST	DEG_SPOP_SBC_1	0.0556
p.P367L	TCGA-EE-A2M5	SKCM	TCGA	PRTST	DEG_SPOP_SBC_1	0.7582
p.P367L	DO222423	MELA	ICGC	PRTST	DEG_SPOP_SBC_1	0.7582
p.P367L	DO37425	SKCM	ICGC	PRTST	DEG_SPOP_SBC_1	0.7582
p.R364L	TCGA-EJ-5517	PRAD	TCGA	PRTST	DEG_SPOP_SBC_1	0.25
p.R364L	DO36305	PRAD	ICGC	PRTST	DEG_SPOP_SBC_1	0.25
p.M381V	DO229240	THCA	ICGC	PRTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3168:3172	PRTST	SPOP	0.987	More...
Q6P2H3	Centrosomal protein of 85 kDa	DEG_SPOP_SBC_1	210:214	PRTST	SPOP	0.9974	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	289:293	PRTST	SPOP	0.9967	More...
Q8TAP9	M-phase-specific PLK1-interacting protein	DEG_SPOP_SBC_1	116:120	PRTST	SPOP	0.9988	More...
Q96C45	Serine/threonine-protein kinase ULK4	DEG_SPOP_SBC_1	367:371	PRTST	SPOP	0.8239	More...
Q9NZN5	Rho guanine nucleotide exchange factor 12	DEG_SPOP_SBC_1	1328:1332	PRTST	SPOP	0.9959	More...
Q9NY43	BarH-like 2 homeobox protein	DEG_SPOP_SBC_1	135:139	PRTST	SPOP	0.77	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1789:1793	PRTST	SPOP	0.7676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons