DegronMD - Q6P2H3(CEP85)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G100W	TCGA-37-4135	LUSC	TCGA	IPTAHVMPS	DEG_SIAH_1	89:97	Mutation rewiring degron network	0.25
p.G100W	DO26806	LUSC	ICGC	IPTAHVMPS	DEG_SIAH_1	89:97	Mutation rewiring degron network	0.25
p.S215N	TCGA-BR-4280	STAD	TCGA	PRTST	DEG_SPOP_SBC_1	210:214	Mutation blocking phosphorylation signal	0.75
p.S215N	DO38663	STAD	ICGC	PRTST	DEG_SPOP_SBC_1	210:214	Mutation blocking phosphorylation signal	0.75
p.Y219C	TCGA-CG-5721	STAD	TCGA	PRTST	DEG_SPOP_SBC_1	210:214	Mutation blocking phosphorylation signal	0.6389
p.Y219C	DO38192	STAD	ICGC	PRTST	DEG_SPOP_SBC_1	210:214	Mutation blocking phosphorylation signal	0.6389
p.P96L	TCGA-FW-A3R5	SKCM	TCGA	IPTAHVMPS	DEG_SIAH_1	89:97	Mutation altering degron motif	0.7582
p.P96L	DO37406	SKCM	ICGC	IPTAHVMPS	DEG_SIAH_1	89:97	Mutation altering degron motif	0.7582
p.H203Y	TCGA-GN-A4U3	SKCM	TCGA	PRTST	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1389
p.H203Y	DO219484	SKCM	ICGC	PRTST	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1389
p.P103S	TCGA-W3-A824	SKCM	TCGA	IPTAHVMPS	DEG_SIAH_1	89:97	Mutation rewiring degron network	0.1667
p.P103S	DO51271	SKCM	ICGC	IPTAHVMPS	DEG_SIAH_1	89:97	Mutation rewiring degron network	0.1667
p.S213N	DO228483	BRCA	ICGC	PRTST	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7069
p.S213N	DO230334	COCA	ICGC	PRTST	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7069
p.S213N	DO229010	COCA	ICGC	PRTST	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7069
p.S213N	DO229016	COCA	ICGC	PRTST	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7069
p.S213N	DO229005	COCA	ICGC	PRTST	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7069
p.S213N	DO229346	LAML	ICGC	PRTST	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7069
p.S213N	DO230659	LAML	ICGC	PRTST	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7069
p.S213N	DO225404	LAML	ICGC	PRTST	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7069
p.S213N	DO231140	LAML	ICGC	PRTST	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7069
p.S213N	DO229047	LICA	ICGC	PRTST	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7069
p.T88I	DO220855	MELA	ICGC	IPTAHVMPS	DEG_SIAH_1	89:97	Mutation rewiring degron network	0.3056
p.P79L	DO27943	ORCA	ICGC	IPTAHVMPS	DEG_SIAH_1	89:97	Mutation rewiring degron network	0.0556

Kaplan plot for CEP85 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP85

UniProt ID: Q6P2H3

Entrez ID: 64793

Protein name: Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CEP85 in