DegronMD

Uniprot ID: Q6P2H3

Source protein: Centrosomal protein of 85 kDa

Source gene: CEP85

Class: DEG_SIAH_1

Location: 89:97

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.797

ASA_SCORE: 63.4778

COIL: 0.6936

CONS_SCORE: 0.5902

DSS_SCORE: 0.5181

HELIX: 0.2338

FCONS_SCORE: 0.829

RIG_SCORE: 0.702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G100W	TCGA-37-4135	LUSC	TCGA	IPTAHVMPS	DEG_SIAH_1	0.25
p.G100W	DO26806	LUSC	ICGC	IPTAHVMPS	DEG_SIAH_1	0.25
p.P96L	TCGA-FW-A3R5	SKCM	TCGA	IPTAHVMPS	DEG_SIAH_1	0.7582
p.P96L	DO37406	SKCM	ICGC	IPTAHVMPS	DEG_SIAH_1	0.7582
p.P103S	TCGA-W3-A824	SKCM	TCGA	IPTAHVMPS	DEG_SIAH_1	0.1667
p.P103S	DO51271	SKCM	ICGC	IPTAHVMPS	DEG_SIAH_1	0.1667
p.T88I	DO220855	MELA	ICGC	IPTAHVMPS	DEG_SIAH_1	0.3056
p.P79L	DO27943	ORCA	ICGC	IPTAHVMPS	DEG_SIAH_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P2H3	Centrosomal protein of 85 kDa	DEG_SIAH_1	89:97	IPTAHVMPS	SIAH1,SIAH2,SIAH3	0.797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons