DegronMD

Uniprot ID: Q96C45

Source protein: Serine/threonine-protein kinase ULK4

Source gene: ULK4

Class: DEG_SCF_FBW7_1

Location: 365:370

E3 ligase: FBXW7

DEGRON score: 0.9384

ASA_SCORE: 96.45

COIL: 0.9235

CONS_SCORE: 0.3214

DSS_SCORE: 0.5789

HELIX: 0.03

FCONS_SCORE: 0.9891

RIG_SCORE: 0.6156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S376R	TCGA-AJ-A3EL	UCEC	TCGA	PTPRTS	DEG_SCF_FBW7_1	0.1667
p.S376R	DO41542	UCEC	ICGC	PTPRTS	DEG_SCF_FBW7_1	0.1667
p.P365H	TCGA-CV-7415	HNSC	TCGA	PTPRTS	DEG_SCF_FBW7_1	0.7694
p.P365H	DO14926	HNSC	ICGC	PTPRTS	DEG_SCF_FBW7_1	0.7694
p.P367L	TCGA-EE-A2M5	SKCM	TCGA	PTPRTS	DEG_SCF_FBW7_1	0.7582
p.P367L	DO222423	MELA	ICGC	PTPRTS	DEG_SCF_FBW7_1	0.7582
p.P367L	DO37425	SKCM	ICGC	PTPRTS	DEG_SCF_FBW7_1	0.7582
p.R364L	TCGA-EJ-5517	PRAD	TCGA	PTPRTS	DEG_SCF_FBW7_1	0.3056
p.R364L	DO36305	PRAD	ICGC	PTPRTS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96C45	Serine/threonine-protein kinase ULK4	DEG_SCF_FBW7_1	365:370	PTPRTS	FBXW7	0.9384	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons