DegronMD

Uniprot ID: Q96C45

Source protein: Serine/threonine-protein kinase ULK4

Source gene: ULK4

Class: LIG_APCC_ABBA_1

Location: 4:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8259

ASA_SCORE: 70.05

COIL: 0.0417

CONS_SCORE: 0.6244

DSS_SCORE: 0.3583

HELIX: 0.0007

FCONS_SCORE: 1.0752

RIG_SCORE: 0.9172

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2Q	TCGA-55-6969	LUAD	TCGA	FILYEE	LIG_APCC_ABBA_1	0.3889
p.E2Q	DO24586	LUAD	ICGC	FILYEE	LIG_APCC_ABBA_1	0.3889
p.K15N	TCGA-AP-A056	UCEC	TCGA	FILYEE	LIG_APCC_ABBA_1	0.2778
p.K15N	TCGA-DK-AA71	BLCA	TCGA	FILYEE	LIG_APCC_ABBA_1	0.2778
p.K15N	DO219010	BLCA	ICGC	FILYEE	LIG_APCC_ABBA_1	0.2778
p.K15N	DO43971	UCEC	ICGC	FILYEE	LIG_APCC_ABBA_1	0.2778
p.T16N	TCGA-Q1-A73R	CESC	TCGA	FILYEE	LIG_APCC_ABBA_1	0.1389
p.T16N	DO49984	CESC	ICGC	FILYEE	LIG_APCC_ABBA_1	0.1389
p.V18A	SIDM01653	Non-Cancerous	GDSC	FILYEE	LIG_APCC_ABBA_1	0.0833
p.V18A	SIDM00207	Glioblastoma	GDSC	FILYEE	LIG_APCC_ABBA_1	0.0833
p.V18A	ACH-002230	Brain Cancer	CCLE	FILYEE	LIG_APCC_ABBA_1	0.0833
p.V18A	ACH-002351	Non-Cancerous	CCLE	FILYEE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96C45	Serine/threonine-protein kinase ULK4	LIG_APCC_ABBA_1	4:9	FILYEE	APC,CDC20,FZR1	0.8259	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons