DegronMD

Uniprot ID: Q9NY43

Source protein: BarH-like 2 homeobox protein

Source gene: BARHL2

Class: DEG_SCF_FBW7_2

Location: 167:174

E3 ligase: FBXW7

DEGRON score: 0.7872

ASA_SCORE: 98.9625

COIL: 0.8306

CONS_SCORE: 0.3175

DSS_SCORE: 0.6637

HELIX: 0.1575

FCONS_SCORE: 0.9091

RIG_SCORE: 0.5754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P184Q	TCGA-18-4083	LUSC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	0.0556
p.P184Q	DO26504	LUSC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	0.0556
p.P184T	TCGA-A5-A1OF	UCEC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	0.0556
p.P184T	DO228952	LICA	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	0.0556
p.P184T	DO42568	UCEC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	0.0556
p.A177T	TCGA-AJ-A8CW	UCEC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	0.25
p.A177T	TCGA-B5-A3FA	UCEC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	0.25
p.A177T	DO52400	UCEC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	0.25
p.A177T	DO52402	UCEC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	0.25
p.P171L	TCGA-B7-A5TI	STAD	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	0.7582
p.P171L	DO222328	STAD	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	0.7582
p.S175I	TCGA-DF-A2KZ	UCEC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	0.3056
p.S175I	DO52409	UCEC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	0.3056
p.P167H	TCGA-EE-A2GL	SKCM	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	0.7694
p.P167H	DO37434	SKCM	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	0.7694
p.E180D	TCGA-F5-6814	READ	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	0.1667
p.E180D	DO36556	READ	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	0.1667
p.A158T	TCGA-FI-A2D5	UCEC	TCGA	PHHTPKQE	DEG_SCF_FBW7_2	0.0833
p.A158T	DO41331	UCEC	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	0.0833
p.F182V	DO234412	ESAD	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	0.1111
p.N176K	DO228952	LICA	ICGC	PHHTPKQE	DEG_SCF_FBW7_2	0.2778
p.H168N	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PHHTPKQE	DEG_SCF_FBW7_2	0.6312
p.H168N	ACH-002272	Lymphoma	CCLE	PHHTPKQE	DEG_SCF_FBW7_2	0.6312
p.H168N	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PHHTPKQE	DEG_SCF_FBW7_2	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NY43	BarH-like 2 homeobox protein	DEG_SCF_FBW7_2	167:174	PHHTPKQE	FBXW7	0.7872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons