DegronMD - O60583(CCNT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S435Y	TCGA-AG-A002	READ	TCGA	PISTT	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.0833
p.S480Y	TCGA-B5-A3FA	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	472:476	Mutation blocking phosphorylation signal	0.6667
p.S480Y	DO8730	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	472:476	Mutation blocking phosphorylation signal	0.6667
p.S480Y	DO52402	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	472:476	Mutation blocking phosphorylation signal	0.6667
p.G468W	TCGA-EE-A2GO	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2222
p.G468W	DO37823	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2222
p.S480F	DO228471	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	472:476	Mutation blocking phosphorylation signal	0.6667
p.P431A	DO45092	LIRI	ICGC	PISTT	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.1944
p.S424F	DO222395	MELA	ICGC	PISTT	DEG_SPOP_SBC_1	422:426	Mutation altering degron motif	0.7982
p.Q432P	SIDM00240	Cervical Carcinoma	GDSC	PISTT	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.1667
p.Q432P	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PISTT	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.1667
p.Q432P	ACH-000241	Leukemia	CCLE	PISTT	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.1667
p.Q432P	ACH-002180	Cervical Cancer	CCLE	PISTT	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.1667
p.Q432P	OMC-1	cervix	COSMIC	PISTT	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.1667
p.T425I	ACH-001516	Cervical Cancer	CCLE	PISTT	DEG_SPOP_SBC_1	422:426	Mutation altering degron motif	0.7078
p.T425I	ACH-001645	Skin Cancer	CCLE	PISTT	DEG_SPOP_SBC_1	422:426	Mutation altering degron motif	0.7078
p.T425I	ACH-001652	Endometrial/Uterine Cancer	CCLE	PISTT	DEG_SPOP_SBC_1	422:426	Mutation altering degron motif	0.7078

Kaplan plot for CCNT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCNT2

UniProt ID: O60583

Entrez ID: 905

Protein name: Cyclin-T2 (CycT2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCNT2 in