DegronMD

Uniprot ID: O60583

Source protein: Cyclin-T2

Source gene: CCNT2

Class: DEG_SPOP_SBC_1

Location: 422:426

E3 ligase: SPOP

DEGRON score: 0.9748

ASA_SCORE: 92.04

COIL: 0.964

CONS_SCORE: 0.3186

DSS_SCORE: 0.6853

HELIX: 0.0142

FCONS_SCORE: 0.9695

RIG_SCORE: 0.6157

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S435Y	TCGA-AG-A002	READ	TCGA	PISTT	DEG_SPOP_SBC_1	0.0833
p.P431A	DO45092	LIRI	ICGC	PISTT	DEG_SPOP_SBC_1	0.1944
p.S424F	DO222395	MELA	ICGC	PISTT	DEG_SPOP_SBC_1	0.7982
p.Q432P	SIDM00240	Cervical Carcinoma	GDSC	PISTT	DEG_SPOP_SBC_1	0.1667
p.Q432P	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PISTT	DEG_SPOP_SBC_1	0.1667
p.Q432P	ACH-000241	Leukemia	CCLE	PISTT	DEG_SPOP_SBC_1	0.1667
p.Q432P	ACH-002180	Cervical Cancer	CCLE	PISTT	DEG_SPOP_SBC_1	0.1667
p.Q432P	OMC-1	cervix	COSMIC	PISTT	DEG_SPOP_SBC_1	0.1667
p.T425I	ACH-001516	Cervical Cancer	CCLE	PISTT	DEG_SPOP_SBC_1	0.7078
p.T425I	ACH-001645	Skin Cancer	CCLE	PISTT	DEG_SPOP_SBC_1	0.7078
p.T425I	ACH-001652	Endometrial/Uterine Cancer	CCLE	PISTT	DEG_SPOP_SBC_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60583	Cyclin-T2	DEG_SPOP_SBC_1	422:426	PISTT	SPOP	0.9748	More...
O75112	LIM domain-binding protein 3	DEG_SPOP_SBC_1	88:92	PISTT	SPOP	0.9903	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1457:1461	PISTT	SPOP	0.5827	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1894:1898	PISTT	SPOP	0.979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons