DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SPOP_SBC_1

Location: 1457:1461

E3 ligase: SPOP

DEGRON score: 0.5827

ASA_SCORE: 102.52

COIL: 0.92

CONS_SCORE: 0.3069

DSS_SCORE: 0.8119

HELIX: 0.0136

FCONS_SCORE: 1.0071

RIG_SCORE: 0.5623

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1448S	DO50970	LICA	ICGC	PISTT	DEG_SPOP_SBC_1	0.0833
p.P1466L	DO220885	MELA	ICGC	PISTT	DEG_SPOP_SBC_1	0.1944
p.P1448L	DO233484	PRAD	ICGC	PISTT	DEG_SPOP_SBC_1	0.0833
p.P1448L	DO233464	PRAD	ICGC	PISTT	DEG_SPOP_SBC_1	0.0833
p.S1460T	DO229470	SKCA	ICGC	PISTT	DEG_SPOP_SBC_1	0.7116
p.S1460T	DO218847	SKCA	ICGC	PISTT	DEG_SPOP_SBC_1	0.7116
p.I1459T	DO218847	SKCA	ICGC	PISTT	DEG_SPOP_SBC_1	0.7078
p.I1459T	DO229510	SKCA	ICGC	PISTT	DEG_SPOP_SBC_1	0.7078
p.P1449L	ACH-000714	Myeloma	CCLE	PISTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60583	Cyclin-T2	DEG_SPOP_SBC_1	422:426	PISTT	SPOP	0.9748	More...
O75112	LIM domain-binding protein 3	DEG_SPOP_SBC_1	88:92	PISTT	SPOP	0.9903	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1457:1461	PISTT	SPOP	0.5827	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1894:1898	PISTT	SPOP	0.979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons