DegronMD - O75112(LDB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L78H	TCGA-95-7567	LUAD	TCGA	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0556
p.L78H	DO25564	LUAD	ICGC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0556
p.P431H	TCGA-BQ-7049	KIRP	TCGA	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.6583
p.P431H	DO20853	KIRP	ICGC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.6583
p.R85C	TCGA-BR-4370	STAD	TCGA	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.25
p.R85C	DO222798	COCA	ICGC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.25
p.R85C	DO38499	STAD	ICGC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.25
p.P99L	TCGA-EE-A29E	SKCM	TCGA	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1389
p.P99L	DO37831	SKCM	ICGC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1389
p.P423L	TCGA-EE-A2GD	SKCM	TCGA	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.7582
p.P423L	DO37603	SKCM	ICGC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.7582
p.P423L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.7582
p.N428S	DO6934	CLLE	ICGC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.7069
p.P86S	DO227802	COCA	ICGC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2778
p.P95A	DO222705	ESCA	ICGC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.25
p.T435P	DO228618	GACA	ICGC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation rewiring degron network	0.2778
p.T435P	DO231007	LUSC	ICGC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation rewiring degron network	0.2778
p.A93T	DO50970	LICA	ICGC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.3056
p.S437P	DO229133	THCA	ICGC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation rewiring degron network	0.2222
p.S437P	DO229140	THCA	ICGC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation rewiring degron network	0.2222
p.S437P	DO229144	THCA	ICGC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation rewiring degron network	0.2222
p.S437P	DO229092	THCA	ICGC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation rewiring degron network	0.2222
p.P101L	SIDM01265	Plasma Cell Myeloma	GDSC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.P101L	SIDM00656	Burkitt's Lymphoma	GDSC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.P101L	SIDM00633	Breast Carcinoma	GDSC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.P101L	SIDM00930	Osteosarcoma	GDSC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.P101L	SIDM00721	Small Cell Lung Carcinoma	GDSC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.P101L	SIDM00257	Neuroblastoma	GDSC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.P101L	SIDM00641	Burkitt's Lymphoma	GDSC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.T91M	SIDM00905	Cervical Carcinoma	GDSC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.7423
p.T91M	ACH-001334	Cervical Cancer	CCLE	PISTT	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.7423
p.T91M	C-4-I	cervix	COSMIC	PISTT	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.7423
p.A427T	SIDM00526	Chronic Myelogenous Leukemia	GDSC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.7139
p.A427T	SIDM01378	Ovarian Carcinoma	GDSC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.7139
p.A427T	SIDM01774	Pancreatic Carcinoma	GDSC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.7139
p.A427T	SIDM00016	Neuroblastoma	GDSC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.7139
p.A427T	MEG-01	haematopoietic and lymphoid tissue	COSMIC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.7139
p.T432I	SIDM00526	Chronic Myelogenous Leukemia	GDSC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.7078
p.T432I	MEG-01	haematopoietic and lymphoid tissue	COSMIC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.7078
p.P423R	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.7512
p.T427I	ACH-000072	Leukemia	CCLE	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.5966
p.T427I	MEG-01	haematopoietic and lymphoid tissue	COSMIC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.5966
p.P418L	ACH-000995	Leukemia	CCLE	NYSPTPYTPSP	CBL_PTK	423:433	Mutation rewiring degron network	0.1944
p.A422T	MEG-01	haematopoietic and lymphoid tissue	COSMIC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation rewiring degron network	0.3056
p.G442S	C-33-A	cervix	COSMIC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation rewiring degron network	0.0833
p.R423M	NCI-H1299	lung	COSMIC	NYSPTPYTPSP	CBL_PTK	423:433	Mutation altering degron motif	0.8632

Kaplan plot for LDB3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LDB3

UniProt ID: O75112

Entrez ID: 11155

Protein name: LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LDB3 in