DegronMD

Uniprot ID: O75112

Source protein: LIM domain-binding protein 3

Source gene: LDB3

Class: CBL_PTK

Location: 423:433

E3 ligase: CBL

DEGRON score: 0.9582

ASA_SCORE: 96.3182

COIL: 0.9607

CONS_SCORE: 0.5107

DSS_SCORE: 0.4914

HELIX: 0.0104

FCONS_SCORE: 1.1141

RIG_SCORE: 0.5799

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P431H	TCGA-BQ-7049	KIRP	TCGA	NYSPTPYTPSP	CBL_PTK	0.6583
p.P431H	DO20853	KIRP	ICGC	NYSPTPYTPSP	CBL_PTK	0.6583
p.P423L	TCGA-EE-A2GD	SKCM	TCGA	NYSPTPYTPSP	CBL_PTK	0.7582
p.P423L	DO37603	SKCM	ICGC	NYSPTPYTPSP	CBL_PTK	0.7582
p.P423L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NYSPTPYTPSP	CBL_PTK	0.7582
p.N428S	DO6934	CLLE	ICGC	NYSPTPYTPSP	CBL_PTK	0.7069
p.T435P	DO228618	GACA	ICGC	NYSPTPYTPSP	CBL_PTK	0.2778
p.T435P	DO231007	LUSC	ICGC	NYSPTPYTPSP	CBL_PTK	0.2778
p.S437P	DO229133	THCA	ICGC	NYSPTPYTPSP	CBL_PTK	0.2222
p.S437P	DO229140	THCA	ICGC	NYSPTPYTPSP	CBL_PTK	0.2222
p.S437P	DO229144	THCA	ICGC	NYSPTPYTPSP	CBL_PTK	0.2222
p.S437P	DO229092	THCA	ICGC	NYSPTPYTPSP	CBL_PTK	0.2222
p.A427T	SIDM00526	Chronic Myelogenous Leukemia	GDSC	NYSPTPYTPSP	CBL_PTK	0.7139
p.A427T	SIDM01378	Ovarian Carcinoma	GDSC	NYSPTPYTPSP	CBL_PTK	0.7139
p.A427T	SIDM01774	Pancreatic Carcinoma	GDSC	NYSPTPYTPSP	CBL_PTK	0.7139
p.A427T	SIDM00016	Neuroblastoma	GDSC	NYSPTPYTPSP	CBL_PTK	0.7139
p.A427T	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	NYSPTPYTPSP	CBL_PTK	0.7139
p.T432I	SIDM00526	Chronic Myelogenous Leukemia	GDSC	NYSPTPYTPSP	CBL_PTK	0.7078
p.T432I	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	NYSPTPYTPSP	CBL_PTK	0.7078
p.P423R	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	NYSPTPYTPSP	CBL_PTK	0.7512
p.T427I	ACH-000072	Leukemia	CCLE	NYSPTPYTPSP	CBL_PTK	0.5966
p.T427I	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	NYSPTPYTPSP	CBL_PTK	0.5966
p.P418L	ACH-000995	Leukemia	CCLE	NYSPTPYTPSP	CBL_PTK	0.1944
p.A422T	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	NYSPTPYTPSP	CBL_PTK	0.3056
p.G442S	C-33-A	cervix	COSMIC	NYSPTPYTPSP	CBL_PTK	0.0833
p.R423M	NCI-H1299	lung	COSMIC	NYSPTPYTPSP	CBL_PTK	0.8632

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75112	LIM domain-binding protein 3	CBL_PTK	423:433	NYSPTPYTPSP	CBL	0.9582	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NYSPTPYTPSP

Degron related mutations and impact score

Drug responses associated with LDB3 mutations

All proteins holding degron of NYSPTPYTPSP