DegronMD

Uniprot ID: O75112

Source protein: LIM domain-binding protein 3

Source gene: LDB3

Class: DEG_SPOP_SBC_1

Location: 88:92

E3 ligase: SPOP

DEGRON score: 0.9903

ASA_SCORE: 97.66

COIL: 0.9442

CONS_SCORE: 0.518

DSS_SCORE: 0.5936

HELIX: 0.02

FCONS_SCORE: 1.0587

RIG_SCORE: 0.6563

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L78H	TCGA-95-7567	LUAD	TCGA	PISTT	DEG_SPOP_SBC_1	0.0556
p.L78H	DO25564	LUAD	ICGC	PISTT	DEG_SPOP_SBC_1	0.0556
p.R85C	TCGA-BR-4370	STAD	TCGA	PISTT	DEG_SPOP_SBC_1	0.25
p.R85C	DO222798	COCA	ICGC	PISTT	DEG_SPOP_SBC_1	0.25
p.R85C	DO38499	STAD	ICGC	PISTT	DEG_SPOP_SBC_1	0.25
p.P99L	TCGA-EE-A29E	SKCM	TCGA	PISTT	DEG_SPOP_SBC_1	0.1389
p.P99L	DO37831	SKCM	ICGC	PISTT	DEG_SPOP_SBC_1	0.1389
p.P86S	DO227802	COCA	ICGC	PISTT	DEG_SPOP_SBC_1	0.2778
p.P95A	DO222705	ESCA	ICGC	PISTT	DEG_SPOP_SBC_1	0.25
p.A93T	DO50970	LICA	ICGC	PISTT	DEG_SPOP_SBC_1	0.3056
p.P101L	SIDM01265	Plasma Cell Myeloma	GDSC	PISTT	DEG_SPOP_SBC_1	0.0833
p.P101L	SIDM00656	Burkitt's Lymphoma	GDSC	PISTT	DEG_SPOP_SBC_1	0.0833
p.P101L	SIDM00633	Breast Carcinoma	GDSC	PISTT	DEG_SPOP_SBC_1	0.0833
p.P101L	SIDM00930	Osteosarcoma	GDSC	PISTT	DEG_SPOP_SBC_1	0.0833
p.P101L	SIDM00721	Small Cell Lung Carcinoma	GDSC	PISTT	DEG_SPOP_SBC_1	0.0833
p.P101L	SIDM00257	Neuroblastoma	GDSC	PISTT	DEG_SPOP_SBC_1	0.0833
p.P101L	SIDM00641	Burkitt's Lymphoma	GDSC	PISTT	DEG_SPOP_SBC_1	0.0833
p.T91M	SIDM00905	Cervical Carcinoma	GDSC	PISTT	DEG_SPOP_SBC_1	0.7423
p.T91M	ACH-001334	Cervical Cancer	CCLE	PISTT	DEG_SPOP_SBC_1	0.7423
p.T91M	C-4-I	cervix	COSMIC	PISTT	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60583	Cyclin-T2	DEG_SPOP_SBC_1	422:426	PISTT	SPOP	0.9748	More...
O75112	LIM domain-binding protein 3	DEG_SPOP_SBC_1	88:92	PISTT	SPOP	0.9903	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1457:1461	PISTT	SPOP	0.5827	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1894:1898	PISTT	SPOP	0.979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons