DegronMD

Uniprot ID: Q8IZF6

Source protein: Adhesion G-protein coupled receptor G4

Source gene: ADGRG4

Class: DEG_SPOP_SBC_1

Location: 1894:1898

E3 ligase: SPOP

DEGRON score: 0.979

ASA_SCORE: 80.54

COIL: 0.7452

CONS_SCORE: 0.7866

DSS_SCORE: 0.5221

HELIX: 0.015

FCONS_SCORE: 1.0139

RIG_SCORE: 0.7491

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1885T	SIDM00491	Thyroid Gland Carcinoma	GDSC	PISTT	DEG_SPOP_SBC_1	0.0833
p.I1885T	ASH-3	thyroid	COSMIC	PISTT	DEG_SPOP_SBC_1	0.0833
p.S1904Y	SIDM00343	Glioblastoma	GDSC	PISTT	DEG_SPOP_SBC_1	0.1667
p.S1904Y	LN-405	central_nervous_system	COSMIC	PISTT	DEG_SPOP_SBC_1	0.1667
p.G1890R	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PISTT	DEG_SPOP_SBC_1	0.2222
p.G1890R	NCI-H650	lung	COSMIC	PISTT	DEG_SPOP_SBC_1	0.2222
p.M1885V	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PISTT	DEG_SPOP_SBC_1	0.0833
p.Y1895H	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PISTT	DEG_SPOP_SBC_1	0.7229
p.H1899D	NCI-H209	lung	COSMIC	PISTT	DEG_SPOP_SBC_1	0.3056
p.R1905K	M14	skin	COSMIC	PISTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60583	Cyclin-T2	DEG_SPOP_SBC_1	422:426	PISTT	SPOP	0.9748	More...
O75112	LIM domain-binding protein 3	DEG_SPOP_SBC_1	88:92	PISTT	SPOP	0.9903	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1457:1461	PISTT	SPOP	0.5827	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1894:1898	PISTT	SPOP	0.979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons