DegronMD

Uniprot ID: P54259

Source protein: Atrophin-1

Source gene: ATN1

Class: CBL_PTK

Location: 919:928

E3 ligase: CBL

DEGRON score: 0.6765

ASA_SCORE: 56.92

COIL: 0.6169

CONS_SCORE: 0.8744

DSS_SCORE: 0.4185

HELIX: 0.3439

FCONS_SCORE: 1.1985

RIG_SCORE: 0.748

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R935L	TCGA-09-2044	OV	TCGA	NVPALYSSDP	CBL_PTK	0.1389
p.R935L	DO28923	OV	ICGC	NVPALYSSDP	CBL_PTK	0.1389
p.R935Q	TCGA-85-8048	LUSC	TCGA	NVPALYSSDP	CBL_PTK	0.1389
p.R935Q	DO27389	LUSC	ICGC	NVPALYSSDP	CBL_PTK	0.1389
p.V911L	TCGA-EA-A410	CESC	TCGA	NVPALYSSDP	CBL_PTK	0.1111
p.V911L	DO49929	CESC	ICGC	NVPALYSSDP	CBL_PTK	0.1111
p.D927Y	TCGA-F7-7848	HNSC	TCGA	NVPALYSSDP	CBL_PTK	0.6214
p.D927Y	DO14198	HNSC	ICGC	NVPALYSSDP	CBL_PTK	0.6214
p.A910T	DO233088	GACA	ICGC	NVPALYSSDP	CBL_PTK	0.0833
p.D912G	DO34016	PACA	ICGC	NVPALYSSDP	CBL_PTK	0.1389
p.V911M	SIDM00377	Other Sarcomas	GDSC	NVPALYSSDP	CBL_PTK	0.1111
p.V911M	ACH-001655	Endometrial/Uterine Cancer	CCLE	NVPALYSSDP	CBL_PTK	0.1111
p.V911M	SKN	soft_tissue	COSMIC	NVPALYSSDP	CBL_PTK	0.1111
p.R938H	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	0.0556
p.R938H	ACH-002263	Esophageal Cancer	CCLE	NVPALYSSDP	CBL_PTK	0.0556
p.R938H	KYSE-220	oesophagus	COSMIC	NVPALYSSDP	CBL_PTK	0.0556
p.A930G	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	0.2778
p.A930G	SIDM00230	Small Cell Lung Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	0.2778
p.A930G	ACH-000718	Lung Cancer	CCLE	NVPALYSSDP	CBL_PTK	0.2778
p.A930G	IST-SL2	lung	COSMIC	NVPALYSSDP	CBL_PTK	0.2778
p.A930G	NCI-H2291	lung	COSMIC	NVPALYSSDP	CBL_PTK	0.2778
p.A929T	SIDM00277	Acute Myeloid Leukemia	GDSC	NVPALYSSDP	CBL_PTK	0.3056
p.A929T	SIDM00520	Mesothelioma	GDSC	NVPALYSSDP	CBL_PTK	0.3056
p.A929T	SIDM01100	Neuroblastoma	GDSC	NVPALYSSDP	CBL_PTK	0.3056
p.A929T	SIDM00638	Cervical Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	0.3056
p.A929T	SIDM01768	Melanoma	GDSC	NVPALYSSDP	CBL_PTK	0.3056
p.E932V	SIDM00874	Breast Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	0.2222
p.E932V	HCC1937	breast	COSMIC	NVPALYSSDP	CBL_PTK	0.2222
p.S925N	ACH-000966	Ovarian Cancer	CCLE	NVPALYSSDP	CBL_PTK	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NVPALYSSDP

Degron related mutations and impact score

Drug responses associated with ATN1 mutations

All proteins holding degron of NVPALYSSDP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54259	Atrophin-1	CBL_PTK	919:928	NVPALYSSDP	CBL	0.6765	More...