DegronMD

Uniprot ID: P54259

Source protein: Atrophin-1

Source gene: ATN1

Class: CBL_PTK

Location: 919:928

E3 ligase: CBL

DEGRON score: 0.6765

ASA_SCORE: 56.92

COIL: 0.6169

CONS_SCORE: 0.8744

DSS_SCORE: 0.4185

HELIX: 0.3439

FCONS_SCORE: 1.1985

RIG_SCORE: 0.748

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S925N	ACH-000966	Ovarian Cancer	CCLE	NVPALYSSDP	CBL_PTK	0.7069
p.D927Y	TCGA-F7-7848	HNSC	TCGA	NVPALYSSDP	CBL_PTK	0.6214
p.D927Y	DO14198	HNSC	ICGC	NVPALYSSDP	CBL_PTK	0.6214
p.A929T	SIDM00277	Acute Myeloid Leukemia	GDSC	NVPALYSSDP	CBL_PTK	0.3056
p.A929T	SIDM00520	Mesothelioma	GDSC	NVPALYSSDP	CBL_PTK	0.3056
p.A929T	SIDM01100	Neuroblastoma	GDSC	NVPALYSSDP	CBL_PTK	0.3056
p.A929T	SIDM00638	Cervical Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	0.3056
p.A929T	SIDM01768	Melanoma	GDSC	NVPALYSSDP	CBL_PTK	0.3056
p.A930G	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	0.2778
p.A930G	SIDM00230	Small Cell Lung Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	0.2778
p.A930G	ACH-000718	Lung Cancer	CCLE	NVPALYSSDP	CBL_PTK	0.2778
p.A930G	IST-SL2	lung	COSMIC	NVPALYSSDP	CBL_PTK	0.2778
p.A930G	NCI-H2291	lung	COSMIC	NVPALYSSDP	CBL_PTK	0.2778
p.E932V	SIDM00874	Breast Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	0.2222
p.E932V	HCC1937	breast	COSMIC	NVPALYSSDP	CBL_PTK	0.2222
p.R935L	TCGA-09-2044	OV	TCGA	NVPALYSSDP	CBL_PTK	0.1389
p.R935L	DO28923	OV	ICGC	NVPALYSSDP	CBL_PTK	0.1389
p.R935Q	TCGA-85-8048	LUSC	TCGA	NVPALYSSDP	CBL_PTK	0.1389
p.R935Q	DO27389	LUSC	ICGC	NVPALYSSDP	CBL_PTK	0.1389
p.D912G	DO34016	PACA	ICGC	NVPALYSSDP	CBL_PTK	0.1389
p.V911L	TCGA-EA-A410	CESC	TCGA	NVPALYSSDP	CBL_PTK	0.1111
p.V911L	DO49929	CESC	ICGC	NVPALYSSDP	CBL_PTK	0.1111
p.V911M	SIDM00377	Other Sarcomas	GDSC	NVPALYSSDP	CBL_PTK	0.1111
p.V911M	ACH-001655	Endometrial/Uterine Cancer	CCLE	NVPALYSSDP	CBL_PTK	0.1111
p.V911M	SKN	soft_tissue	COSMIC	NVPALYSSDP	CBL_PTK	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54259	Atrophin-1	CBL_PTK	919:928	NVPALYSSDP	CBL	0.6765	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons