DegronMD

Uniprot ID: Q86UE8

Source protein: Serine/threonine-protein kinase tousled-like 2

Source gene: TLK2

Class: DEG_SPOP_SBC_1

Location: 749:753

E3 ligase: SPOP

DEGRON score: 0.9974

ASA_SCORE: 74.04

COIL: 0.93

CONS_SCORE: 0.3301

DSS_SCORE: 0.3535

HELIX: 0.034

FCONS_SCORE: 0.8251

RIG_SCORE: 0.6516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T740A	TCGA-A6-5665	COAD	TCGA	VSTSS	DEG_SPOP_SBC_1	0.0833
p.T740A	ACH-002179	Breast Cancer	CCLE	VSTSS	DEG_SPOP_SBC_1	0.0833
p.T740A	OCUB-M	breast	COSMIC	VSTSS	DEG_SPOP_SBC_1	0.0833
p.S748Y	TCGA-AX-A0J0	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.3056
p.A743V	TCGA-CK-4951	COAD	TCGA	VSTSS	DEG_SPOP_SBC_1	0.1667
p.S741Y	TCGA-CN-6010	HNSC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.1111
p.S739A	TCGA-US-A774	PAAD	TCGA	VSTSS	DEG_SPOP_SBC_1	0.0556
p.T762A	SIDM00241	Breast Carcinoma	GDSC	VSTSS	DEG_SPOP_SBC_1	0.0833
p.T762A	OCUB-M	breast	COSMIC	VSTSS	DEG_SPOP_SBC_1	0.0833
p.S763F	ACH-000923	Lymphoma	CCLE	VSTSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35716	Transcription factor SOX-11	DEG_SPOP_SBC_1	339:343	VSTSS	SPOP	0.9784	More...
P42684	Tyrosine-protein kinase ABL2	DEG_SPOP_SBC_1	816:820	VSTSS	SPOP	0.9961	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	38:42	VSTSS	SPOP	0.9947	More...
P57768	Sorting nexin-16	DEG_SPOP_SBC_1	33:37	VSTSS	SPOP	0.9979	More...
Q14149	MORC family CW-type zinc finger protein 3	DEG_SPOP_SBC_1	872:876	VSTSS	SPOP	0.9439	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	776:780	VSTSS	SPOP	0.6894	More...
Q6PJT7	Zinc finger CCCH domain-containing protein 14	DEG_SPOP_SBC_1	131:135	VSTSS	SPOP	0.9971	More...
Q76L83	Putative Polycomb group protein ASXL2	DEG_SPOP_SBC_1	1333:1337	VSTSS	SPOP	0.961	More...
Q7L1W4	Volume-regulated anion channel subunit LRRC8D	DEG_SPOP_SBC_1	238:242	VSTSS	SPOP	0.6957	More...
Q86UE8	Serine/threonine-protein kinase tousled-like 2	DEG_SPOP_SBC_1	749:753	VSTSS	SPOP	0.9974	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1839:1843	VSTSS	SPOP	0.9049	More...
Q8NFU7	Methylcytosine dioxygenase TET1	DEG_SPOP_SBC_1	569:573	VSTSS	SPOP	0.9917	More...
Q8TF72	Protein Shroom3	DEG_SPOP_SBC_1	815:819	VSTSS	SPOP	0.9994	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	162:166	VSTSS	SPOP	0.9894	More...
Q9ULM3	YEATS domain-containing protein 2	DEG_SPOP_SBC_1	888:892	VSTSS	SPOP	0.9942	More...
Q9Y4D8	Probable E3 ubiquitin-protein ligase HECTD4	DEG_SPOP_SBC_1	3049:3053	VSTSS	SPOP	0.9533	More...
Q9BQE6	LBH domain-containing protein 1	DEG_SPOP_SBC_1	51:55	VSTSS	SPOP	0.5933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons