DegronMD - Q9Y4D8(HECTD4)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A3068S	TCGA-55-A490	LUAD	TCGA	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation rewiring degron network	0.1111
p.K1089I	TCGA-CC-A7IH	LIHC	TCGA	ISGTPAET	DEG_SCF_FBW7_1	1074:1081	Mutation rewiring degron network	0.1111
p.R3046W	TCGA-EO-A22U	UCEC	TCGA	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation rewiring degron network	0.0833
p.R3046W	TCGA-EO-A22U	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation rewiring degron network	0.25
p.R3046W	TCGA-WS-AB45	COAD	TCGA	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation rewiring degron network	0.0833
p.R3046W	TCGA-WS-AB45	COAD	TCGA	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation rewiring degron network	0.25
p.E3043K	TCGA-MV-A51V	BLCA	TCGA	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation rewiring degron network	0.1667
p.S3053F	TCGA-Z2-AA3S	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation altering degron motif	0.7982
p.S1075C	DO49757	BLCA	ICGC	ISGTPAET	DEG_SCF_FBW7_1	1074:1081	Mutation altering degron motif	0.7541
p.M3059I	DO219723	CESC	ICGC	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation altering degron motif	0.6507
p.T3056P	DO222571	COCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation altering degron motif	0.7031
p.S3060R	DO229031	LICA	ICGC	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation altering degron motif	0.7427
p.A3063P	DO26772	LUSC	ICGC	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation rewiring degron network	0.25
p.A3063P	DO26772	LUSC	ICGC	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation rewiring degron network	0.0556
p.Q3069H	DO50733	ORCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation rewiring degron network	0.0833
p.P3042H	DO36304	PRAD	ICGC	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation rewiring degron network	0.1389
p.P3042S	DO48546	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation rewiring degron network	0.1389
p.A3063T	DO37839	SKCM	ICGC	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation rewiring degron network	0.25
p.A3063T	DO37839	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation rewiring degron network	0.0556
p.P3057T	DO37405	SKCM	ICGC	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation altering degron motif	0.7031
p.S3066F	DO48665	SKCM	ICGC	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation rewiring degron network	0.1667
p.A1083S	DO38926	THCA	ICGC	ISGTPAET	DEG_SCF_FBW7_1	1074:1081	Mutation rewiring degron network	0.2778
p.A1083V	DO219774	UCEC	ICGC	ISGTPAET	DEG_SCF_FBW7_1	1074:1081	Mutation rewiring degron network	0.2778
p.A1065T	DO42713	UCEC	ICGC	ISGTPAET	DEG_SCF_FBW7_1	1074:1081	Mutation rewiring degron network	0.0833
p.G3044D	SIDM00663	Melanoma	GDSC	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation rewiring degron network	0.1944
p.G3044D	Hs939-T	skin	COSMIC	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation rewiring degron network	0.1944
p.N1076K	SIDM00730	Small Cell Lung Carcinoma	GDSC	ISGTPAET	DEG_SCF_FBW7_1	1074:1081	Mutation altering degron motif	0.6918
p.N1076K	NCI-H2227	lung	COSMIC	ISGTPAET	DEG_SCF_FBW7_1	1074:1081	Mutation altering degron motif	0.6918
p.A3059V	SIDM00225	Melanoma	GDSC	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation altering degron motif	0.6936
p.A3059V	IST-MEL1	skin	COSMIC	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation altering degron motif	0.6936
p.R3049Q	SIDM00153	T-Lymphoblastic Leukemia	GDSC	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation altering degron motif	0.7329
p.A3049T	ACH-000303	Gastric Cancer	CCLE	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation altering degron motif	0.7139
p.P3061S	ACH-000945	Lung Cancer	CCLE	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation rewiring degron network	0.3056
p.P3061S	ACH-000945	Lung Cancer	CCLE	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation rewiring degron network	0.1111
p.A3061T	NCI-SNU-5	stomach	COSMIC	LTPAMS	DEG_SCF_FBW7_1	3055:3060	Mutation rewiring degron network	0.3056
p.A3061T	NCI-SNU-5	stomach	COSMIC	VSTSS	DEG_SPOP_SBC_1	3049:3053	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HECTD4

UniProt ID: Q9Y4D8

Entrez ID:

Protein name: Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HECTD4 in