DegronMD

Uniprot ID: Q9Y4D8

Source protein: Probable E3 ubiquitin-protein ligase HECTD4

Source gene: HECTD4

Class: DEG_SCF_FBW7_1

Location: 1074:1081

E3 ligase: FBXW7

DEGRON score: 0.6409

ASA_SCORE: 65.5

COIL: 0.87

CONS_SCORE: 0.4147

DSS_SCORE: 0.4705

HELIX: 0.0549

FCONS_SCORE: 0.9517

RIG_SCORE: 0.6668

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1089I	TCGA-CC-A7IH	LIHC	TCGA	ISGTPAET	DEG_SCF_FBW7_1	0.1111
p.S1075C	DO49757	BLCA	ICGC	ISGTPAET	DEG_SCF_FBW7_1	0.7541
p.A1083S	DO38926	THCA	ICGC	ISGTPAET	DEG_SCF_FBW7_1	0.2778
p.A1083V	DO219774	UCEC	ICGC	ISGTPAET	DEG_SCF_FBW7_1	0.2778
p.A1065T	DO42713	UCEC	ICGC	ISGTPAET	DEG_SCF_FBW7_1	0.0833
p.N1076K	SIDM00730	Small Cell Lung Carcinoma	GDSC	ISGTPAET	DEG_SCF_FBW7_1	0.6918
p.N1076K	NCI-H2227	lung	COSMIC	ISGTPAET	DEG_SCF_FBW7_1	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4D8	Probable E3 ubiquitin-protein ligase HECTD4	DEG_SCF_FBW7_1	1074:1081	ISGTPAET	FBXW7	0.6409	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons