DegronMD

Uniprot ID: Q9Y4D8

Source protein: Probable E3 ubiquitin-protein ligase HECTD4

Source gene: HECTD4

Class: DEG_SCF_FBW7_1

Location: 3055:3060

E3 ligase: FBXW7

DEGRON score: 0.9647

ASA_SCORE: 71.9333

COIL: 0.796

CONS_SCORE: 0.41

DSS_SCORE: 0.4509

HELIX: 0.1365

FCONS_SCORE: 1.1317

RIG_SCORE: 0.6999

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3068S	TCGA-55-A490	LUAD	TCGA	LTPAMS	DEG_SCF_FBW7_1	0.1111
p.R3046W	TCGA-EO-A22U	UCEC	TCGA	LTPAMS	DEG_SCF_FBW7_1	0.0833
p.R3046W	TCGA-WS-AB45	COAD	TCGA	LTPAMS	DEG_SCF_FBW7_1	0.0833
p.M3059I	DO219723	CESC	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.6507
p.T3056P	DO222571	COCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.7031
p.S3060R	DO229031	LICA	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.7427
p.A3063P	DO26772	LUSC	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.25
p.Q3069H	DO50733	ORCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.0833
p.A3063T	DO37839	SKCM	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.25
p.P3057T	DO37405	SKCM	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.7031
p.S3066F	DO48665	SKCM	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.1667
p.A3059V	SIDM00225	Melanoma	GDSC	LTPAMS	DEG_SCF_FBW7_1	0.6936
p.A3059V	IST-MEL1	skin	COSMIC	LTPAMS	DEG_SCF_FBW7_1	0.6936
p.P3061S	ACH-000945	Lung Cancer	CCLE	LTPAMS	DEG_SCF_FBW7_1	0.3056
p.A3061T	NCI-SNU-5	stomach	COSMIC	LTPAMS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15230	Laminin subunit alpha-5	DEG_SCF_FBW7_1	1254:1259	LTPAMS	FBXW7	0.5545	More...
Q9Y4D8	Probable E3 ubiquitin-protein ligase HECTD4	DEG_SCF_FBW7_1	3055:3060	LTPAMS	FBXW7	0.9647	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons