DegronMD - O15230(LAMA5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1704W	TCGA-3B-A9HT	SARC	TCGA	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.0833
p.R1704W	TCGA-3B-A9HT	SARC	TCGA	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.2222
p.R1704W	DO219934	SARC	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.0833
p.R1704W	DO219934	SARC	ICGC	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.2222
p.R1704W	SIDM00623	Other Blood Cancers	GDSC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.0833
p.R1704W	SIDM00623	Other Blood Cancers	GDSC	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.2222
p.R1704W	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.0833
p.R1704W	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.2222
p.R1264Q	TCGA-AD-6964	COAD	TCGA	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.1944
p.R1264Q	DO8360	COAD	ICGC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.1944
p.E1687Q	TCGA-B8-5164	KIRC	TCGA	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.1944
p.E1687Q	TCGA-B8-5164	KIRC	TCGA	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.0556
p.E1687Q	DO17018	KIRC	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.1944
p.E1687Q	DO17018	KIRC	ICGC	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.0556
p.R1722W	TCGA-C5-A1M8	CESC	TCGA	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.25
p.R1722W	DO48993	CESC	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.25
p.R1722W	SIDM00668	Non-Cancerous	GDSC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.25
p.R1722W	ACH-002245	Lymphoma	CCLE	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.25
p.R1722W	Hs-445	haematopoietic and lymphoid tissue	COSMIC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.25
p.L1678M	TCGA-D1-A2G0	UCEC	TCGA	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation altering degron motif	0.711
p.L1678M	DO43049	UCEC	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation altering degron motif	0.711
p.G1710R	TCGA-DA-A95Y	SKCM	TCGA	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.25
p.G1710R	TCGA-DA-A95Y	SKCM	TCGA	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.0556
p.G1710R	DO223908	SKCM	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.25
p.G1710R	DO223908	SKCM	ICGC	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.0556
p.P1728L	TCGA-EE-A20C	SKCM	TCGA	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.0833
p.P1728L	DO47665	SKCM	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.0833
p.P1728S	TCGA-EE-A20C	SKCM	TCGA	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.0833
p.P1728S	DO47665	SKCM	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.0833
p.T1671A	TCGA-EO-A22X	UCEC	TCGA	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.25
p.T1671A	DO43907	UCEC	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.25
p.R1266Q	TCGA-HT-8564	LGG	TCGA	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.1389
p.R1266Q	DO44623	LGG	ICGC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.1389
p.V1681M	TCGA-L5-A43E	ESCA	TCGA	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation altering degron motif	0.6097
p.R1679W	DO222768	BTCA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation altering degron motif	0.7523
p.E1666K	DO224685	COCA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.1111
p.M1258T	DO229010	COCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation altering degron motif	0.6312
p.M1258T	DO229013	COCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation altering degron motif	0.6312
p.M1258T	DO229016	COCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation altering degron motif	0.6312
p.M1258T	DO229003	COCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation altering degron motif	0.6312
p.M1258T	DO229005	COCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation altering degron motif	0.6312
p.G1709S	DO233709	GACA	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.2222
p.G1709S	DO233709	GACA	ICGC	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.0833
p.V1681L	DO228924	LICA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation altering degron motif	0.5654
p.A1684D	DO228974	LICA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.2778
p.H1665Q	DO229022	LICA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.0833
p.T1671K	DO229038	LICA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.25
p.A1251T	DO50777	LICA	ICGC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.25
p.A1251T	DO41199	UCEC	ICGC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.25
p.A1251T	SIDM00901	Endometrial Carcinoma	GDSC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.25
p.A1251T	ACH-000940	Endometrial/Uterine Cancer	CCLE	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.25
p.R1667W	DO230550	LUSC	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.1389
p.D1253N	DO222662	MELA	ICGC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.3056
p.P1728F	DO222775	MELA	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.0833
p.P1265H	DO232838	NACA	ICGC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.1667
p.L1712H	DO232842	NACA	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.3056
p.H1250L	DO233294	NACA	ICGC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.2222
p.L1712P	DO233299	NACA	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.3056
p.D1703G	DO218878	SKCA	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation rewiring degron network	0.0556
p.D1703G	DO218878	SKCA	ICGC	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.25
p.A1251V	DO38380	STAD	ICGC	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.25
p.A1688S	DO229268	THCA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.1667
p.A1688S	DO229268	THCA	ICGC	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.0833
p.R1667Q	SIDM01268	Colorectal Carcinoma	GDSC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.1389
p.R1667Q	SIDM00233	T-Lymphoblastic Leukemia	GDSC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.1389
p.R1667Q	SIDM00164	Biliary Tract Carcinoma	GDSC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.1389
p.E1691K	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.0833
p.E1691K	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.1667
p.E1691K	ACH-000784	Esophageal Cancer	CCLE	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.0833
p.E1691K	ACH-000784	Esophageal Cancer	CCLE	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.1667
p.E1691K	KYSE-70	oesophagus	COSMIC	LRADLRHVP	DEG_APCC_DBOX_1	1674:1682	Mutation rewiring degron network	0.0833
p.E1691K	KYSE-70	oesophagus	COSMIC	PPSY	ITCH	1697:1700	Mutation rewiring degron network	0.1667
p.L1716R	SIDM00167	Head and Neck Carcinoma	GDSC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation altering degron motif	0.8428
p.L1716R	SIDM01444	Glioblastoma	GDSC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation altering degron motif	0.8428
p.L1716R	SIDM00497	Colorectal Carcinoma	GDSC	RYELHSE	LIG_APCC_ABBAyCdc20_2	1713:1719	Mutation altering degron motif	0.8428
p.G1245S	ACH-000706	Lung Cancer	CCLE	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.0833
p.R1266W	ACH-000810	Skin Cancer	CCLE	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.1389
p.M1258I	ACH-000866	Lung Cancer	CCLE	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation altering degron motif	0.6507
p.P1260A	ACH-002446	Gastric Cancer	CCLE	LTPAMS	DEG_SCF_FBW7_1	1254:1259	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LAMA5

UniProt ID: O15230

Entrez ID: 3911

Protein name: Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LAMA5 in