DegronMD

Uniprot ID: O15230

Source protein: Laminin subunit alpha-5

Source gene: LAMA5

Class: DEG_APCC_DBOX_1

Location: 1674:1682

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8684

ASA_SCORE: 53.3778

COIL: 0.5657

CONS_SCORE: 0.3353

DSS_SCORE: 0.4581

HELIX: 0.1618

FCONS_SCORE: 1.2646

RIG_SCORE: 0.7612

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1687Q	TCGA-B8-5164	KIRC	TCGA	LRADLRHVP	DEG_APCC_DBOX_1	0.1944
p.E1687Q	DO17018	KIRC	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	0.1944
p.L1678M	TCGA-D1-A2G0	UCEC	TCGA	LRADLRHVP	DEG_APCC_DBOX_1	0.711
p.L1678M	DO43049	UCEC	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	0.711
p.T1671A	TCGA-EO-A22X	UCEC	TCGA	LRADLRHVP	DEG_APCC_DBOX_1	0.25
p.T1671A	DO43907	UCEC	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	0.25
p.V1681M	TCGA-L5-A43E	ESCA	TCGA	LRADLRHVP	DEG_APCC_DBOX_1	0.6097
p.R1679W	DO222768	BTCA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	0.7523
p.E1666K	DO224685	COCA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	0.1111
p.V1681L	DO228924	LICA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	0.5654
p.A1684D	DO228974	LICA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	0.2778
p.H1665Q	DO229022	LICA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	0.0833
p.T1671K	DO229038	LICA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	0.25
p.R1667W	DO230550	LUSC	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	0.1389
p.A1688S	DO229268	THCA	ICGC	LRADLRHVP	DEG_APCC_DBOX_1	0.1667
p.R1667Q	SIDM01268	Colorectal Carcinoma	GDSC	LRADLRHVP	DEG_APCC_DBOX_1	0.1389
p.R1667Q	SIDM00233	T-Lymphoblastic Leukemia	GDSC	LRADLRHVP	DEG_APCC_DBOX_1	0.1389
p.R1667Q	SIDM00164	Biliary Tract Carcinoma	GDSC	LRADLRHVP	DEG_APCC_DBOX_1	0.1389
p.E1691K	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	LRADLRHVP	DEG_APCC_DBOX_1	0.0833
p.E1691K	ACH-000784	Esophageal Cancer	CCLE	LRADLRHVP	DEG_APCC_DBOX_1	0.0833
p.E1691K	KYSE-70	oesophagus	COSMIC	LRADLRHVP	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15230	Laminin subunit alpha-5	DEG_APCC_DBOX_1	1674:1682	LRADLRHVP	APC,CDC20,FZR1	0.8684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons