DegronMD

Uniprot ID: O15230

Source protein: Laminin subunit alpha-5

Source gene: LAMA5

Class: DEG_SCF_FBW7_1

Location: 1254:1259

E3 ligase: FBXW7

DEGRON score: 0.5545

ASA_SCORE: 61.7

COIL: 0.7693

CONS_SCORE: 0.2166

DSS_SCORE: 0.7216

HELIX: 0.2092

FCONS_SCORE: 0.8577

RIG_SCORE: 0.6179

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1264Q	TCGA-AD-6964	COAD	TCGA	LTPAMS	DEG_SCF_FBW7_1	0.1944
p.R1264Q	DO8360	COAD	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.1944
p.R1266Q	TCGA-HT-8564	LGG	TCGA	LTPAMS	DEG_SCF_FBW7_1	0.1389
p.R1266Q	DO44623	LGG	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.1389
p.M1258T	DO229010	COCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.6312
p.M1258T	DO229013	COCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.6312
p.M1258T	DO229016	COCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.6312
p.M1258T	DO229003	COCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.6312
p.M1258T	DO229005	COCA	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.6312
p.A1251T	DO50777	LICA	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.25
p.A1251T	DO41199	UCEC	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.25
p.A1251T	SIDM00901	Endometrial Carcinoma	GDSC	LTPAMS	DEG_SCF_FBW7_1	0.25
p.A1251T	ACH-000940	Endometrial/Uterine Cancer	CCLE	LTPAMS	DEG_SCF_FBW7_1	0.25
p.D1253N	DO222662	MELA	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.3056
p.P1265H	DO232838	NACA	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.1667
p.H1250L	DO233294	NACA	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.2222
p.A1251V	DO38380	STAD	ICGC	LTPAMS	DEG_SCF_FBW7_1	0.25
p.G1245S	ACH-000706	Lung Cancer	CCLE	LTPAMS	DEG_SCF_FBW7_1	0.0833
p.R1266W	ACH-000810	Skin Cancer	CCLE	LTPAMS	DEG_SCF_FBW7_1	0.1389
p.M1258I	ACH-000866	Lung Cancer	CCLE	LTPAMS	DEG_SCF_FBW7_1	0.6507
p.P1260A	ACH-002446	Gastric Cancer	CCLE	LTPAMS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15230	Laminin subunit alpha-5	DEG_SCF_FBW7_1	1254:1259	LTPAMS	FBXW7	0.5545	More...
Q9Y4D8	Probable E3 ubiquitin-protein ligase HECTD4	DEG_SCF_FBW7_1	3055:3060	LTPAMS	FBXW7	0.9647	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons