DegronMD

Uniprot ID: O15230

Source protein: Laminin subunit alpha-5

Source gene: LAMA5

Class: LIG_APCC_ABBAyCdc20_2

Location: 1713:1719

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7196

ASA_SCORE: 47.1

COIL: 0.1549

CONS_SCORE: 0.4428

DSS_SCORE: 0.3651

HELIX: 0.007

FCONS_SCORE: 1.0552

RIG_SCORE: 0.7702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1704W	TCGA-3B-A9HT	SARC	TCGA	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1704W	DO219934	SARC	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1704W	SIDM00623	Other Blood Cancers	GDSC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1704W	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1722W	TCGA-C5-A1M8	CESC	TCGA	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.R1722W	DO48993	CESC	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.R1722W	SIDM00668	Non-Cancerous	GDSC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.R1722W	ACH-002245	Lymphoma	CCLE	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.R1722W	Hs-445	haematopoietic_and_lymphoid_tissue	COSMIC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.G1710R	TCGA-DA-A95Y	SKCM	TCGA	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.G1710R	DO223908	SKCM	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.P1728L	TCGA-EE-A20C	SKCM	TCGA	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P1728L	DO47665	SKCM	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P1728S	TCGA-EE-A20C	SKCM	TCGA	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P1728S	DO47665	SKCM	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G1709S	DO233709	GACA	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P1728F	DO222775	MELA	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.L1712H	DO232842	NACA	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.L1712P	DO233299	NACA	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D1703G	DO218878	SKCA	ICGC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L1716R	SIDM00167	Head and Neck Carcinoma	GDSC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.8428
p.L1716R	SIDM01444	Glioblastoma	GDSC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.8428
p.L1716R	SIDM00497	Colorectal Carcinoma	GDSC	RYELHSE	LIG_APCC_ABBAyCdc20_2	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15230	Laminin subunit alpha-5	LIG_APCC_ABBAyCdc20_2	1713:1719	RYELHSE	APC,CDC20,FZR1	0.7196	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RYELHSE

Degron related mutations and impact score

Drug responses associated with LAMA5 mutations

All proteins holding degron of RYELHSE