DegronMD - Q14149(MORC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N486H	TCGA-A5-A2K5	UCEC	TCGA	LSTPSFS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.0556
p.N486H	DO41379	UCEC	ICGC	LSTPSFS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.0556
p.S629L	TCGA-AC-A5XS	BRCA	TCGA	TAATQTEVPSL	DEG_COP1_1	637:647	Mutation rewiring degron network	0.1111
p.S629L	DO50023	BRCA	ICGC	TAATQTEVPSL	DEG_COP1_1	637:647	Mutation rewiring degron network	0.1111
p.S497L	TCGA-AX-A2HC	UCEC	TCGA	LSTPSFS	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.7667
p.S497L	DO41572	UCEC	ICGC	LSTPSFS	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.7667
p.A495T	TCGA-B7-A5TN	STAD	TCGA	LSTPSFS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.3056
p.A495T	DO222331	STAD	ICGC	LSTPSFS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.3056
p.D657N	TCGA-BR-8680	STAD	TCGA	TAATQTEVPSL	DEG_COP1_1	637:647	Mutation rewiring degron network	0.0556
p.D657N	DO47769	STAD	ICGC	TAATQTEVPSL	DEG_COP1_1	637:647	Mutation rewiring degron network	0.0556
p.T874K	TCGA-BT-A3PJ	BLCA	TCGA	VSTSS	DEG_SPOP_SBC_1	872:876	Mutation altering degron motif	0.7306
p.T874K	DO44097	BLCA	ICGC	VSTSS	DEG_SPOP_SBC_1	872:876	Mutation altering degron motif	0.7306
p.R492Q	TCGA-CJ-6027	KIRC	TCGA	LSTPSFS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.2222
p.R492Q	DO18312	KIRC	ICGC	LSTPSFS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.2222
p.D633Y	TCGA-E7-A85H	BLCA	TCGA	TAATQTEVPSL	DEG_COP1_1	637:647	Mutation rewiring degron network	0.2222
p.D633Y	DO219018	BLCA	ICGC	TAATQTEVPSL	DEG_COP1_1	637:647	Mutation rewiring degron network	0.2222
p.A638S	DO229018	LICA	ICGC	TAATQTEVPSL	DEG_COP1_1	637:647	Mutation altering degron motif	0.6477
p.A869S	DO229045	LICA	ICGC	VSTSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.R631P	DO220176	SARC	ICGC	TAATQTEVPSL	DEG_COP1_1	637:647	Mutation rewiring degron network	0.1667
p.S502P	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	LSTPSFS	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.6752
p.S502P	ACH-000865	Esophageal Cancer	CCLE	LSTPSFS	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.6752
p.S502P	KYSE-450	oesophagus	COSMIC	LSTPSFS	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.6752

Kaplan plot for MORC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MORC3

UniProt ID: Q14149

Entrez ID: 23515

Protein name: MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MORC3 in