DegronMD

Uniprot ID: Q14149

Source protein: MORC family CW-type zinc finger protein 3

Source gene: MORC3

Class: DEG_COP1_1

Location: 637:647

E3 ligase: COP1

DEGRON score: 0.9033

ASA_SCORE: 85.7091

COIL: 0.7268

CONS_SCORE: 0.5731

DSS_SCORE: 0.4971

HELIX: 0.0928

FCONS_SCORE: 1.0313

RIG_SCORE: 0.7414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S629L	TCGA-AC-A5XS	BRCA	TCGA	TAATQTEVPSL	DEG_COP1_1	0.1111
p.S629L	DO50023	BRCA	ICGC	TAATQTEVPSL	DEG_COP1_1	0.1111
p.D657N	TCGA-BR-8680	STAD	TCGA	TAATQTEVPSL	DEG_COP1_1	0.0556
p.D657N	DO47769	STAD	ICGC	TAATQTEVPSL	DEG_COP1_1	0.0556
p.D633Y	TCGA-E7-A85H	BLCA	TCGA	TAATQTEVPSL	DEG_COP1_1	0.2222
p.D633Y	DO219018	BLCA	ICGC	TAATQTEVPSL	DEG_COP1_1	0.2222
p.A638S	DO229018	LICA	ICGC	TAATQTEVPSL	DEG_COP1_1	0.6477
p.R631P	DO220176	SARC	ICGC	TAATQTEVPSL	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14149	MORC family CW-type zinc finger protein 3	DEG_COP1_1	637:647	TAATQTEVPSL	COP1	0.9033	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons